Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations

Seongwon Cha, Imhoi Koo, Sun M. Choi, Byung L. Park, Kil S. Kim, Jae Ryong Kim, Hyoung D. Shin, Jong Y. Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: While INSIG2 has been reported to be associated with BMI in many populations, conflicting results have prevented consensus over its role. In analyses of mice and cell cultures the gene has been found to be involved in the regulation of cholesterol synthesis; however, no relationship has been found with cholesterol metabolism in human epidemiological research. Therefore, this study attempts to assess the effect of rs7566605 near INSIG2 on both obesity- and cholesterol-related traits in Koreans. Methods: The rs7566605 polymorphism was genotyped with 2,364 Koreans, and associations with obesity- and cholesterol-related traits were analyzed statistically via an ANOVA or T-test. Results: Replication of an association with BMI, WHR, fat mass, fat percent, and abdominal fat area failed, and the C allele of rs7566605 was not associated significantly with total cholesterol, HDL cholesterol, or triglyceride. However, it was found in a meta-analysis of a dominant model that the C allele of rs7566605 appeared to affect the level of the total cholesterol, especially in female subjects. Conclusion: We failed to show associations of rs7566605 with cholesterol- and obesity-related phenotypes, although we newly suggest the possible involvement of INSIG2 with the plasma level of the total cholesterol in women.

Original languageEnglish (US)
Article number1471
Number of pages1
JournalBMC Medical Genetics
Volume10
DOIs
StatePublished - Sep 22 2009

Fingerprint

Obesity
Cholesterol
Population
Fats
Alleles
Abdominal Fat
HDL Cholesterol
Meta-Analysis
Analysis of Variance
Triglycerides
Cell Culture Techniques
Phenotype
Research
Genes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Cha, Seongwon ; Koo, Imhoi ; Choi, Sun M. ; Park, Byung L. ; Kim, Kil S. ; Kim, Jae Ryong ; Shin, Hyoung D. ; Kim, Jong Y. / Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations. In: BMC Medical Genetics. 2009 ; Vol. 10.
@article{11446fd0fab440499c441c534355f74f,
title = "Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations",
abstract = "Background: While INSIG2 has been reported to be associated with BMI in many populations, conflicting results have prevented consensus over its role. In analyses of mice and cell cultures the gene has been found to be involved in the regulation of cholesterol synthesis; however, no relationship has been found with cholesterol metabolism in human epidemiological research. Therefore, this study attempts to assess the effect of rs7566605 near INSIG2 on both obesity- and cholesterol-related traits in Koreans. Methods: The rs7566605 polymorphism was genotyped with 2,364 Koreans, and associations with obesity- and cholesterol-related traits were analyzed statistically via an ANOVA or T-test. Results: Replication of an association with BMI, WHR, fat mass, fat percent, and abdominal fat area failed, and the C allele of rs7566605 was not associated significantly with total cholesterol, HDL cholesterol, or triglyceride. However, it was found in a meta-analysis of a dominant model that the C allele of rs7566605 appeared to affect the level of the total cholesterol, especially in female subjects. Conclusion: We failed to show associations of rs7566605 with cholesterol- and obesity-related phenotypes, although we newly suggest the possible involvement of INSIG2 with the plasma level of the total cholesterol in women.",
author = "Seongwon Cha and Imhoi Koo and Choi, {Sun M.} and Park, {Byung L.} and Kim, {Kil S.} and Kim, {Jae Ryong} and Shin, {Hyoung D.} and Kim, {Jong Y.}",
year = "2009",
month = "9",
day = "22",
doi = "10.1186/1471-2350-10-96",
language = "English (US)",
volume = "10",
journal = "BMC Medical Genetics",
issn = "1471-2350",
publisher = "BioMed Central",

}

Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations. / Cha, Seongwon; Koo, Imhoi; Choi, Sun M.; Park, Byung L.; Kim, Kil S.; Kim, Jae Ryong; Shin, Hyoung D.; Kim, Jong Y.

In: BMC Medical Genetics, Vol. 10, 1471, 22.09.2009.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations

AU - Cha, Seongwon

AU - Koo, Imhoi

AU - Choi, Sun M.

AU - Park, Byung L.

AU - Kim, Kil S.

AU - Kim, Jae Ryong

AU - Shin, Hyoung D.

AU - Kim, Jong Y.

PY - 2009/9/22

Y1 - 2009/9/22

N2 - Background: While INSIG2 has been reported to be associated with BMI in many populations, conflicting results have prevented consensus over its role. In analyses of mice and cell cultures the gene has been found to be involved in the regulation of cholesterol synthesis; however, no relationship has been found with cholesterol metabolism in human epidemiological research. Therefore, this study attempts to assess the effect of rs7566605 near INSIG2 on both obesity- and cholesterol-related traits in Koreans. Methods: The rs7566605 polymorphism was genotyped with 2,364 Koreans, and associations with obesity- and cholesterol-related traits were analyzed statistically via an ANOVA or T-test. Results: Replication of an association with BMI, WHR, fat mass, fat percent, and abdominal fat area failed, and the C allele of rs7566605 was not associated significantly with total cholesterol, HDL cholesterol, or triglyceride. However, it was found in a meta-analysis of a dominant model that the C allele of rs7566605 appeared to affect the level of the total cholesterol, especially in female subjects. Conclusion: We failed to show associations of rs7566605 with cholesterol- and obesity-related phenotypes, although we newly suggest the possible involvement of INSIG2 with the plasma level of the total cholesterol in women.

AB - Background: While INSIG2 has been reported to be associated with BMI in many populations, conflicting results have prevented consensus over its role. In analyses of mice and cell cultures the gene has been found to be involved in the regulation of cholesterol synthesis; however, no relationship has been found with cholesterol metabolism in human epidemiological research. Therefore, this study attempts to assess the effect of rs7566605 near INSIG2 on both obesity- and cholesterol-related traits in Koreans. Methods: The rs7566605 polymorphism was genotyped with 2,364 Koreans, and associations with obesity- and cholesterol-related traits were analyzed statistically via an ANOVA or T-test. Results: Replication of an association with BMI, WHR, fat mass, fat percent, and abdominal fat area failed, and the C allele of rs7566605 was not associated significantly with total cholesterol, HDL cholesterol, or triglyceride. However, it was found in a meta-analysis of a dominant model that the C allele of rs7566605 appeared to affect the level of the total cholesterol, especially in female subjects. Conclusion: We failed to show associations of rs7566605 with cholesterol- and obesity-related phenotypes, although we newly suggest the possible involvement of INSIG2 with the plasma level of the total cholesterol in women.

UR - http://www.scopus.com/inward/record.url?scp=70349908393&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349908393&partnerID=8YFLogxK

U2 - 10.1186/1471-2350-10-96

DO - 10.1186/1471-2350-10-96

M3 - Article

C2 - 19772594

AN - SCOPUS:70349908393

VL - 10

JO - BMC Medical Genetics

JF - BMC Medical Genetics

SN - 1471-2350

M1 - 1471

ER -