Association and linkage of α-2A adrenergic receptor gene polymorphisms with childhood ADHD

L. Park, J. T. Nigg, I. D. Waldman, K. A. Nummy, C. Huang-Pollock, M. Rappley, K. H. Friderici

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Abstract

Attention-deficit hyperactivity disorder (ADHD) is a heritable disorder, prevalent from childhood through adulthood. Although the noradrenergic (NA) system is thought to mediate a portion of the pathophysiology of ADHD, genes in this pathway have not been investigated as frequently as those in the dopaminergic system. Previous association studies of one candidate gene in the NA system, ADRA2A, showed inconsistent results with regard to an MspI polymorphism. In the current study, two nearby single-nucleotide polymorphisms, which define HhaI and DraI restriction fragment length polymorphisms, were also genotyped and were in significant linkage disequilibrium with the MspI RFLP. Transmission disequilibrium tests (TDTs) in a sample of 177 nuclear families showed significant association and linkage of the DraI polymorphism with the ADHD combined subtype (P = 0.03), and the quantitative TDT showed association of this polymorphism with the inattentive (P = 0.003) and hyperactive-impulsive (P = 0.015) symptom dimensions. The haplotype that contained the less common allele of the DraI polymorphism likewise showed a strong relationship with the inattentive (P = 0.001) and hyperactive-impulsive (P = 0.004) symptom dimensions. This study supports the hypothesis that an allele of the ADRA2A gene is associated and linked with the ADHD combined subtype and suggests that the DraI polymorphism of ADRA2A is linked to a causative polymorphism.

Original languageEnglish (US)
Pages (from-to)572-580
Number of pages9
JournalMolecular Psychiatry
Volume10
Issue number6
DOIs
StatePublished - Jun 1 2005

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Attention Deficit Disorder with Hyperactivity
Adrenergic Receptors
Restriction Fragment Length Polymorphisms
Genes
Alleles
Linkage Disequilibrium
Genetic Association Studies
Nuclear Family
Haplotypes
Single Nucleotide Polymorphism

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Park, L., Nigg, J. T., Waldman, I. D., Nummy, K. A., Huang-Pollock, C., Rappley, M., & Friderici, K. H. (2005). Association and linkage of α-2A adrenergic receptor gene polymorphisms with childhood ADHD. Molecular Psychiatry, 10(6), 572-580. https://doi.org/10.1038/sj.mp.4001605
Park, L. ; Nigg, J. T. ; Waldman, I. D. ; Nummy, K. A. ; Huang-Pollock, C. ; Rappley, M. ; Friderici, K. H. / Association and linkage of α-2A adrenergic receptor gene polymorphisms with childhood ADHD. In: Molecular Psychiatry. 2005 ; Vol. 10, No. 6. pp. 572-580.
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Park, L, Nigg, JT, Waldman, ID, Nummy, KA, Huang-Pollock, C, Rappley, M & Friderici, KH 2005, 'Association and linkage of α-2A adrenergic receptor gene polymorphisms with childhood ADHD', Molecular Psychiatry, vol. 10, no. 6, pp. 572-580. https://doi.org/10.1038/sj.mp.4001605

Association and linkage of α-2A adrenergic receptor gene polymorphisms with childhood ADHD. / Park, L.; Nigg, J. T.; Waldman, I. D.; Nummy, K. A.; Huang-Pollock, C.; Rappley, M.; Friderici, K. H.

In: Molecular Psychiatry, Vol. 10, No. 6, 01.06.2005, p. 572-580.

Research output: Contribution to journalArticle

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AU - Nigg, J. T.

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