Association between β-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: A report from the NHLBI-sponsored WISE study

S. G. Terra, S. P. McGorray, R. Wu, D. M. McNamara, L. H. Cavallari, J. R. Walker, M. R. Wallace, B. D. Johnson, C. N. Bairey Merz, G. Sopko, C. J. Pepine, J. A. Johnson

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: The β-adrenergic receptor (βAR) genes are candidate genes for obesity because of their roles in energy homeostasis and promotion of lipolysis in human adipose tissue. Objective is to determine the association between obesity and polymorphisms in genes of the β1AR (ADRB1), β2AR (ADRB2), β3AR (ADRB3), Gs protein alpha (GNAS1), to which all three β-receptors couple and the G protein β3 subunit (GNB3), to which β3ARs couple. DESIGN: A case-control genetic association study. SUBJECTS: A total of 643 black or white women enrolled in Women's Ischemia Syndrome Evaluation (WISE) study. MEASUREMENTS: Genotypes were determined by PCR with single primer extension. Associations between genotype and body mass index (BMI), waist-to-hip ratio (WHR), waist circumference, and obesity were made. RESULTS: Polymorphisms in the three βAR genes, GNAS1, and GNB3 were not associated with BMI, WHR, waist circumference, or obesity. Linear and logistic regression analyses found no contribution of either genotype or haplotype with anthropometric measurements or obesity. CONCLUSIONS: Our study suggests that among American women with suspected coronary heart disease, polymorphisms in the βARs and their G-protein-coupled receptors do not contribute to increased BMI, WHR, waist circumference, or obesity. Given that 50% of all women die from coronary heart disease, and a higher percentage have heart disease during their lifetime, our results are likely generalizable to many American women.

Original languageEnglish (US)
Pages (from-to)746-754
Number of pages9
JournalInternational Journal of Obesity
Volume29
Issue number7
DOIs
StatePublished - Jul 1 2005

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National Heart, Lung, and Blood Institute (U.S.)
G-Protein-Coupled Receptors
Adrenergic Receptors
Body Mass Index
Ischemia
Obesity
Waist-Hip Ratio
Waist Circumference
Genotype
Genes
Coronary Disease
Lipolysis
Protein Subunits
Genetic Association Studies
GTP-Binding Proteins
Haplotypes
Adipose Tissue
Linear Models
Heart Diseases
Homeostasis

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Terra, S. G. ; McGorray, S. P. ; Wu, R. ; McNamara, D. M. ; Cavallari, L. H. ; Walker, J. R. ; Wallace, M. R. ; Johnson, B. D. ; Bairey Merz, C. N. ; Sopko, G. ; Pepine, C. J. ; Johnson, J. A. / Association between β-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women : A report from the NHLBI-sponsored WISE study. In: International Journal of Obesity. 2005 ; Vol. 29, No. 7. pp. 746-754.
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abstract = "OBJECTIVES: The β-adrenergic receptor (βAR) genes are candidate genes for obesity because of their roles in energy homeostasis and promotion of lipolysis in human adipose tissue. Objective is to determine the association between obesity and polymorphisms in genes of the β1AR (ADRB1), β2AR (ADRB2), β3AR (ADRB3), Gs protein alpha (GNAS1), to which all three β-receptors couple and the G protein β3 subunit (GNB3), to which β3ARs couple. DESIGN: A case-control genetic association study. SUBJECTS: A total of 643 black or white women enrolled in Women's Ischemia Syndrome Evaluation (WISE) study. MEASUREMENTS: Genotypes were determined by PCR with single primer extension. Associations between genotype and body mass index (BMI), waist-to-hip ratio (WHR), waist circumference, and obesity were made. RESULTS: Polymorphisms in the three βAR genes, GNAS1, and GNB3 were not associated with BMI, WHR, waist circumference, or obesity. Linear and logistic regression analyses found no contribution of either genotype or haplotype with anthropometric measurements or obesity. CONCLUSIONS: Our study suggests that among American women with suspected coronary heart disease, polymorphisms in the βARs and their G-protein-coupled receptors do not contribute to increased BMI, WHR, waist circumference, or obesity. Given that 50{\%} of all women die from coronary heart disease, and a higher percentage have heart disease during their lifetime, our results are likely generalizable to many American women.",
author = "Terra, {S. G.} and McGorray, {S. P.} and R. Wu and McNamara, {D. M.} and Cavallari, {L. H.} and Walker, {J. R.} and Wallace, {M. R.} and Johnson, {B. D.} and {Bairey Merz}, {C. N.} and G. Sopko and Pepine, {C. J.} and Johnson, {J. A.}",
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Terra, SG, McGorray, SP, Wu, R, McNamara, DM, Cavallari, LH, Walker, JR, Wallace, MR, Johnson, BD, Bairey Merz, CN, Sopko, G, Pepine, CJ & Johnson, JA 2005, 'Association between β-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: A report from the NHLBI-sponsored WISE study', International Journal of Obesity, vol. 29, no. 7, pp. 746-754. https://doi.org/10.1038/sj.ijo.0802978

Association between β-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women : A report from the NHLBI-sponsored WISE study. / Terra, S. G.; McGorray, S. P.; Wu, R.; McNamara, D. M.; Cavallari, L. H.; Walker, J. R.; Wallace, M. R.; Johnson, B. D.; Bairey Merz, C. N.; Sopko, G.; Pepine, C. J.; Johnson, J. A.

In: International Journal of Obesity, Vol. 29, No. 7, 01.07.2005, p. 746-754.

Research output: Contribution to journalArticle

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T1 - Association between β-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women

T2 - A report from the NHLBI-sponsored WISE study

AU - Terra, S. G.

AU - McGorray, S. P.

AU - Wu, R.

AU - McNamara, D. M.

AU - Cavallari, L. H.

AU - Walker, J. R.

AU - Wallace, M. R.

AU - Johnson, B. D.

AU - Bairey Merz, C. N.

AU - Sopko, G.

AU - Pepine, C. J.

AU - Johnson, J. A.

PY - 2005/7/1

Y1 - 2005/7/1

N2 - OBJECTIVES: The β-adrenergic receptor (βAR) genes are candidate genes for obesity because of their roles in energy homeostasis and promotion of lipolysis in human adipose tissue. Objective is to determine the association between obesity and polymorphisms in genes of the β1AR (ADRB1), β2AR (ADRB2), β3AR (ADRB3), Gs protein alpha (GNAS1), to which all three β-receptors couple and the G protein β3 subunit (GNB3), to which β3ARs couple. DESIGN: A case-control genetic association study. SUBJECTS: A total of 643 black or white women enrolled in Women's Ischemia Syndrome Evaluation (WISE) study. MEASUREMENTS: Genotypes were determined by PCR with single primer extension. Associations between genotype and body mass index (BMI), waist-to-hip ratio (WHR), waist circumference, and obesity were made. RESULTS: Polymorphisms in the three βAR genes, GNAS1, and GNB3 were not associated with BMI, WHR, waist circumference, or obesity. Linear and logistic regression analyses found no contribution of either genotype or haplotype with anthropometric measurements or obesity. CONCLUSIONS: Our study suggests that among American women with suspected coronary heart disease, polymorphisms in the βARs and their G-protein-coupled receptors do not contribute to increased BMI, WHR, waist circumference, or obesity. Given that 50% of all women die from coronary heart disease, and a higher percentage have heart disease during their lifetime, our results are likely generalizable to many American women.

AB - OBJECTIVES: The β-adrenergic receptor (βAR) genes are candidate genes for obesity because of their roles in energy homeostasis and promotion of lipolysis in human adipose tissue. Objective is to determine the association between obesity and polymorphisms in genes of the β1AR (ADRB1), β2AR (ADRB2), β3AR (ADRB3), Gs protein alpha (GNAS1), to which all three β-receptors couple and the G protein β3 subunit (GNB3), to which β3ARs couple. DESIGN: A case-control genetic association study. SUBJECTS: A total of 643 black or white women enrolled in Women's Ischemia Syndrome Evaluation (WISE) study. MEASUREMENTS: Genotypes were determined by PCR with single primer extension. Associations between genotype and body mass index (BMI), waist-to-hip ratio (WHR), waist circumference, and obesity were made. RESULTS: Polymorphisms in the three βAR genes, GNAS1, and GNB3 were not associated with BMI, WHR, waist circumference, or obesity. Linear and logistic regression analyses found no contribution of either genotype or haplotype with anthropometric measurements or obesity. CONCLUSIONS: Our study suggests that among American women with suspected coronary heart disease, polymorphisms in the βARs and their G-protein-coupled receptors do not contribute to increased BMI, WHR, waist circumference, or obesity. Given that 50% of all women die from coronary heart disease, and a higher percentage have heart disease during their lifetime, our results are likely generalizable to many American women.

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