TY - JOUR
T1 - Association between 5,10-Methylenetetrahydrofolate Reductase C677T Gene Polymorphism and Risk of Ischemic Stroke
T2 - A Meta-analysis
AU - Song, Yanli
AU - Li, Bohong
AU - Wang, Chunjuan
AU - Wang, Penglian
AU - Gao, Xiang
AU - Liu, Gaifen
N1 - Funding Information:
Sources of funding: This research was supported by grants from the National Natural Science Foundation of China (Grant No. 81200914 ), the Ministry of Science and Technology and the Ministry of Health of the People's Republic of China (Grant No. 2011BAI08B01 ), Beijing Biobank of Cerebral Vascular Disease ( D131100005313003 ), the Program of Talents by Beijing Municipal ( 2010D003034000012 ), and Beijing Municipal Science and Technology Project ( D131100002313003 ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2016 National Stroke Association. All rights reserved.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background Hyperhomocysteinemia, a condition that is strongly determined by dietary intake of B vitamins, has been suggested to be an independent risk factor for ischemic stroke (IS). To test this hypothesis, we performed a meta-analysis to investigate the associations between 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which plays a critical role in modulating plasma homocysteine concentrations, and IS risk. Materials and Methods We searched case-control studies on the association between MTHFR C677T genetic polymorphism and susceptibility to IS through PubMed, Embase, and Medline databases from January 2000 up to October 2014. The random-effects model was employed because moderate heterogeneity across studies was observed, as assessed by I2 statistic. Publication bias was estimated using funnel plot and Egger's regression test. Results A total of 22 case-control studies were included in the current meta-analysis. Significant associations between MTHFR C677T genetic polymorphism and IS were found under the dominant model (pooled odds ratio [OR] = 1.40, 95% confidence interval [CI]: 1.24-1.57), the recessive model (pooled OR = 1.37, 95% CI: 1.16-1.61), and the allele model (pooled OR = 1.29, 95% CI: 1.18-1.42). Conclusions The meta-analysis suggests that MTHFR C677T genetic polymorphism is significantly associated with susceptibility to IS, which provides evidence supporting hyperhomocysteinemia as a risk factor for stroke.
AB - Background Hyperhomocysteinemia, a condition that is strongly determined by dietary intake of B vitamins, has been suggested to be an independent risk factor for ischemic stroke (IS). To test this hypothesis, we performed a meta-analysis to investigate the associations between 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which plays a critical role in modulating plasma homocysteine concentrations, and IS risk. Materials and Methods We searched case-control studies on the association between MTHFR C677T genetic polymorphism and susceptibility to IS through PubMed, Embase, and Medline databases from January 2000 up to October 2014. The random-effects model was employed because moderate heterogeneity across studies was observed, as assessed by I2 statistic. Publication bias was estimated using funnel plot and Egger's regression test. Results A total of 22 case-control studies were included in the current meta-analysis. Significant associations between MTHFR C677T genetic polymorphism and IS were found under the dominant model (pooled odds ratio [OR] = 1.40, 95% confidence interval [CI]: 1.24-1.57), the recessive model (pooled OR = 1.37, 95% CI: 1.16-1.61), and the allele model (pooled OR = 1.29, 95% CI: 1.18-1.42). Conclusions The meta-analysis suggests that MTHFR C677T genetic polymorphism is significantly associated with susceptibility to IS, which provides evidence supporting hyperhomocysteinemia as a risk factor for stroke.
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U2 - 10.1016/j.jstrokecerebrovasdis.2015.11.041
DO - 10.1016/j.jstrokecerebrovasdis.2015.11.041
M3 - Article
C2 - 26776436
AN - SCOPUS:84959536708
VL - 25
SP - 679
EP - 687
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
SN - 1052-3057
IS - 3
ER -