Association between attention bias to threat and anxiety symptoms in children and adolescents

Rany Abend, Leone de Voogd, Elske Salemink, Reinout W. Wiers, Koraly Elisa Perez-Edgar, Amanda Fitzgerald, Lauren K. White, Giovanni A. Salum, Jie He, Wendy K. Silverman, Jeremy W. Pettit, Daniel S. Pine, Yair Bar-Haim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Considerable research links threat-related attention biases to anxiety symptoms in adults, whereas extant findings on threat biases in youth are limited and mixed. Inconsistent findings may arise due to substantial methodological variability and limited sample sizes, emphasizing the need for systematic research on large samples. The aim of this report is to examine the association between threat bias and pediatric anxiety symptoms using standardized measures in a large, international, multi-site youth sample. Methods: A total of 1,291 children and adolescents from seven research sites worldwide completed standardized attention bias assessment task (dot-probe task) and child anxiety symptoms measure (Screen for Child Anxiety Related Emotional Disorders). Using a dimensional approach to symptomatology, we conducted regression analyses predicting overall, and disorder-specific, anxiety symptoms severity, based on threat bias scores. Results: Threat bias correlated positively with overall anxiety symptoms severity (ß = 0.078, P =.004). Furthermore, threat bias was positively associated specifically with social anxiety (ß = 0.072, P =.008) and school phobia (ß = 0.076, P =.006) symptoms severity, but not with panic, generalized anxiety, or separation anxiety symptoms. These associations were not moderated by age or gender. Conclusions: These findings indicate associations between threat bias and pediatric anxiety symptoms, and suggest that vigilance to external threats manifests more prominently in symptoms of social anxiety and school phobia, regardless of age and gender. These findings point to the role of attention bias to threat in anxiety, with implications for translational clinical research. The significance of applying standardized methods in multi-site collaborations for overcoming challenges inherent to clinical research is discussed.

Original languageEnglish (US)
Pages (from-to)229-238
Number of pages10
JournalDepression and anxiety
Volume35
Issue number3
DOIs
StatePublished - Mar 1 2018

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Anxiety
Phobic Disorders
Research
Separation Anxiety
Pediatrics
Panic
Translational Medical Research
Anxiety Disorders
Sample Size
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Abend, R., de Voogd, L., Salemink, E., Wiers, R. W., Perez-Edgar, K. E., Fitzgerald, A., ... Bar-Haim, Y. (2018). Association between attention bias to threat and anxiety symptoms in children and adolescents. Depression and anxiety, 35(3), 229-238. https://doi.org/10.1002/da.22706
Abend, Rany ; de Voogd, Leone ; Salemink, Elske ; Wiers, Reinout W. ; Perez-Edgar, Koraly Elisa ; Fitzgerald, Amanda ; White, Lauren K. ; Salum, Giovanni A. ; He, Jie ; Silverman, Wendy K. ; Pettit, Jeremy W. ; Pine, Daniel S. ; Bar-Haim, Yair. / Association between attention bias to threat and anxiety symptoms in children and adolescents. In: Depression and anxiety. 2018 ; Vol. 35, No. 3. pp. 229-238.
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Abend, R, de Voogd, L, Salemink, E, Wiers, RW, Perez-Edgar, KE, Fitzgerald, A, White, LK, Salum, GA, He, J, Silverman, WK, Pettit, JW, Pine, DS & Bar-Haim, Y 2018, 'Association between attention bias to threat and anxiety symptoms in children and adolescents', Depression and anxiety, vol. 35, no. 3, pp. 229-238. https://doi.org/10.1002/da.22706

Association between attention bias to threat and anxiety symptoms in children and adolescents. / Abend, Rany; de Voogd, Leone; Salemink, Elske; Wiers, Reinout W.; Perez-Edgar, Koraly Elisa; Fitzgerald, Amanda; White, Lauren K.; Salum, Giovanni A.; He, Jie; Silverman, Wendy K.; Pettit, Jeremy W.; Pine, Daniel S.; Bar-Haim, Yair.

In: Depression and anxiety, Vol. 35, No. 3, 01.03.2018, p. 229-238.

Research output: Contribution to journalArticle

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T1 - Association between attention bias to threat and anxiety symptoms in children and adolescents

AU - Abend, Rany

AU - de Voogd, Leone

AU - Salemink, Elske

AU - Wiers, Reinout W.

AU - Perez-Edgar, Koraly Elisa

AU - Fitzgerald, Amanda

AU - White, Lauren K.

AU - Salum, Giovanni A.

AU - He, Jie

AU - Silverman, Wendy K.

AU - Pettit, Jeremy W.

AU - Pine, Daniel S.

AU - Bar-Haim, Yair

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background: Considerable research links threat-related attention biases to anxiety symptoms in adults, whereas extant findings on threat biases in youth are limited and mixed. Inconsistent findings may arise due to substantial methodological variability and limited sample sizes, emphasizing the need for systematic research on large samples. The aim of this report is to examine the association between threat bias and pediatric anxiety symptoms using standardized measures in a large, international, multi-site youth sample. Methods: A total of 1,291 children and adolescents from seven research sites worldwide completed standardized attention bias assessment task (dot-probe task) and child anxiety symptoms measure (Screen for Child Anxiety Related Emotional Disorders). Using a dimensional approach to symptomatology, we conducted regression analyses predicting overall, and disorder-specific, anxiety symptoms severity, based on threat bias scores. Results: Threat bias correlated positively with overall anxiety symptoms severity (ß = 0.078, P =.004). Furthermore, threat bias was positively associated specifically with social anxiety (ß = 0.072, P =.008) and school phobia (ß = 0.076, P =.006) symptoms severity, but not with panic, generalized anxiety, or separation anxiety symptoms. These associations were not moderated by age or gender. Conclusions: These findings indicate associations between threat bias and pediatric anxiety symptoms, and suggest that vigilance to external threats manifests more prominently in symptoms of social anxiety and school phobia, regardless of age and gender. These findings point to the role of attention bias to threat in anxiety, with implications for translational clinical research. The significance of applying standardized methods in multi-site collaborations for overcoming challenges inherent to clinical research is discussed.

AB - Background: Considerable research links threat-related attention biases to anxiety symptoms in adults, whereas extant findings on threat biases in youth are limited and mixed. Inconsistent findings may arise due to substantial methodological variability and limited sample sizes, emphasizing the need for systematic research on large samples. The aim of this report is to examine the association between threat bias and pediatric anxiety symptoms using standardized measures in a large, international, multi-site youth sample. Methods: A total of 1,291 children and adolescents from seven research sites worldwide completed standardized attention bias assessment task (dot-probe task) and child anxiety symptoms measure (Screen for Child Anxiety Related Emotional Disorders). Using a dimensional approach to symptomatology, we conducted regression analyses predicting overall, and disorder-specific, anxiety symptoms severity, based on threat bias scores. Results: Threat bias correlated positively with overall anxiety symptoms severity (ß = 0.078, P =.004). Furthermore, threat bias was positively associated specifically with social anxiety (ß = 0.072, P =.008) and school phobia (ß = 0.076, P =.006) symptoms severity, but not with panic, generalized anxiety, or separation anxiety symptoms. These associations were not moderated by age or gender. Conclusions: These findings indicate associations between threat bias and pediatric anxiety symptoms, and suggest that vigilance to external threats manifests more prominently in symptoms of social anxiety and school phobia, regardless of age and gender. These findings point to the role of attention bias to threat in anxiety, with implications for translational clinical research. The significance of applying standardized methods in multi-site collaborations for overcoming challenges inherent to clinical research is discussed.

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