Association between gait characteristics and endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease

Andrew Gardner, Polly S. Montgomery, Ana I. Casanegra, Federico Silva-Palacios, Zoltan Ungvari, Anna Csiszar

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The aim of the study was to determine whether gait characteristics were associated with endothelial cell inflammation, oxidative stress, and apoptosis and with circulating biomarkers of inflammation and antioxidant capacity in older patients with symptomatic peripheral artery disease (PAD). Gait measurements of 231 symptomatic men and women with PAD were assessed during a 4-m walk test. Patients were further characterized on endothelial effects of circulating factors present in the sera using a cell culture-based bioassay on primary human arterial endothelial cells and on circulating inflammatory and vascular biomarkers. In a multivariate regression model for gait speed, the significant independent variables were age (p < 0.001), intercellular cell adhesion molecule-1 (ICAM-1) (p < 0.001), diabetes (p = 0.003), sex (p = 0.003), and history of cerebrovascular accidents (p = 0.021). In multivariate analyses for gait cadence, the significant independent predictors included high-sensitivity C-reactive protein (HsCRP) (p < 0.001), diabetes (p = 0.001), and hypertension (p = 0.001). In a multivariate regression model for gait stride length, the significant independent variables were HsCRP (p < 0.001), age (p < 0.001), ICAM-1 (p < 0.001), hypertension (p = 0.002), cellular reactive oxygen species production (p = 0.007), and sex (p = 0.008). Higher levels of circulating biomarkers of inflammation and endothelial cell oxidative stress were associated with slower gait speed, slower cadence, and shorter stride length in older symptomatic patients with PAD. Additionally, this profile of impaired gait was more evident in older patients, in women, and in those with diabetes, hypertension, and history of cerebrovascular accidents.

Original languageEnglish (US)
Article number64
JournalAge
Volume38
Issue number3
DOIs
StatePublished - Jun 1 2016

Fingerprint

Peripheral Arterial Disease
Gait
Oxidative Stress
Inflammation
Endothelial Cells
Biomarkers
Cell Adhesion Molecules
Intercellular Adhesion Molecule-1
Hypertension
C-Reactive Protein
Stroke
Biological Assay
Blood Vessels
Reactive Oxygen Species
Multivariate Analysis
Cell Culture Techniques
Antioxidants
Apoptosis
Serum
Walking Speed

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

Cite this

Gardner, Andrew ; Montgomery, Polly S. ; Casanegra, Ana I. ; Silva-Palacios, Federico ; Ungvari, Zoltan ; Csiszar, Anna. / Association between gait characteristics and endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease. In: Age. 2016 ; Vol. 38, No. 3.
@article{9c2520beaa794766bf6398fed743d840,
title = "Association between gait characteristics and endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease",
abstract = "The aim of the study was to determine whether gait characteristics were associated with endothelial cell inflammation, oxidative stress, and apoptosis and with circulating biomarkers of inflammation and antioxidant capacity in older patients with symptomatic peripheral artery disease (PAD). Gait measurements of 231 symptomatic men and women with PAD were assessed during a 4-m walk test. Patients were further characterized on endothelial effects of circulating factors present in the sera using a cell culture-based bioassay on primary human arterial endothelial cells and on circulating inflammatory and vascular biomarkers. In a multivariate regression model for gait speed, the significant independent variables were age (p < 0.001), intercellular cell adhesion molecule-1 (ICAM-1) (p < 0.001), diabetes (p = 0.003), sex (p = 0.003), and history of cerebrovascular accidents (p = 0.021). In multivariate analyses for gait cadence, the significant independent predictors included high-sensitivity C-reactive protein (HsCRP) (p < 0.001), diabetes (p = 0.001), and hypertension (p = 0.001). In a multivariate regression model for gait stride length, the significant independent variables were HsCRP (p < 0.001), age (p < 0.001), ICAM-1 (p < 0.001), hypertension (p = 0.002), cellular reactive oxygen species production (p = 0.007), and sex (p = 0.008). Higher levels of circulating biomarkers of inflammation and endothelial cell oxidative stress were associated with slower gait speed, slower cadence, and shorter stride length in older symptomatic patients with PAD. Additionally, this profile of impaired gait was more evident in older patients, in women, and in those with diabetes, hypertension, and history of cerebrovascular accidents.",
author = "Andrew Gardner and Montgomery, {Polly S.} and Casanegra, {Ana I.} and Federico Silva-Palacios and Zoltan Ungvari and Anna Csiszar",
year = "2016",
month = "6",
day = "1",
doi = "10.1007/s11357-016-9925-y",
language = "English (US)",
volume = "38",
journal = "GeroScience",
issn = "2509-2715",
publisher = "Springer International Publishing AG",
number = "3",

}

Association between gait characteristics and endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease. / Gardner, Andrew; Montgomery, Polly S.; Casanegra, Ana I.; Silva-Palacios, Federico; Ungvari, Zoltan; Csiszar, Anna.

In: Age, Vol. 38, No. 3, 64, 01.06.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between gait characteristics and endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease

AU - Gardner, Andrew

AU - Montgomery, Polly S.

AU - Casanegra, Ana I.

AU - Silva-Palacios, Federico

AU - Ungvari, Zoltan

AU - Csiszar, Anna

PY - 2016/6/1

Y1 - 2016/6/1

N2 - The aim of the study was to determine whether gait characteristics were associated with endothelial cell inflammation, oxidative stress, and apoptosis and with circulating biomarkers of inflammation and antioxidant capacity in older patients with symptomatic peripheral artery disease (PAD). Gait measurements of 231 symptomatic men and women with PAD were assessed during a 4-m walk test. Patients were further characterized on endothelial effects of circulating factors present in the sera using a cell culture-based bioassay on primary human arterial endothelial cells and on circulating inflammatory and vascular biomarkers. In a multivariate regression model for gait speed, the significant independent variables were age (p < 0.001), intercellular cell adhesion molecule-1 (ICAM-1) (p < 0.001), diabetes (p = 0.003), sex (p = 0.003), and history of cerebrovascular accidents (p = 0.021). In multivariate analyses for gait cadence, the significant independent predictors included high-sensitivity C-reactive protein (HsCRP) (p < 0.001), diabetes (p = 0.001), and hypertension (p = 0.001). In a multivariate regression model for gait stride length, the significant independent variables were HsCRP (p < 0.001), age (p < 0.001), ICAM-1 (p < 0.001), hypertension (p = 0.002), cellular reactive oxygen species production (p = 0.007), and sex (p = 0.008). Higher levels of circulating biomarkers of inflammation and endothelial cell oxidative stress were associated with slower gait speed, slower cadence, and shorter stride length in older symptomatic patients with PAD. Additionally, this profile of impaired gait was more evident in older patients, in women, and in those with diabetes, hypertension, and history of cerebrovascular accidents.

AB - The aim of the study was to determine whether gait characteristics were associated with endothelial cell inflammation, oxidative stress, and apoptosis and with circulating biomarkers of inflammation and antioxidant capacity in older patients with symptomatic peripheral artery disease (PAD). Gait measurements of 231 symptomatic men and women with PAD were assessed during a 4-m walk test. Patients were further characterized on endothelial effects of circulating factors present in the sera using a cell culture-based bioassay on primary human arterial endothelial cells and on circulating inflammatory and vascular biomarkers. In a multivariate regression model for gait speed, the significant independent variables were age (p < 0.001), intercellular cell adhesion molecule-1 (ICAM-1) (p < 0.001), diabetes (p = 0.003), sex (p = 0.003), and history of cerebrovascular accidents (p = 0.021). In multivariate analyses for gait cadence, the significant independent predictors included high-sensitivity C-reactive protein (HsCRP) (p < 0.001), diabetes (p = 0.001), and hypertension (p = 0.001). In a multivariate regression model for gait stride length, the significant independent variables were HsCRP (p < 0.001), age (p < 0.001), ICAM-1 (p < 0.001), hypertension (p = 0.002), cellular reactive oxygen species production (p = 0.007), and sex (p = 0.008). Higher levels of circulating biomarkers of inflammation and endothelial cell oxidative stress were associated with slower gait speed, slower cadence, and shorter stride length in older symptomatic patients with PAD. Additionally, this profile of impaired gait was more evident in older patients, in women, and in those with diabetes, hypertension, and history of cerebrovascular accidents.

UR - http://www.scopus.com/inward/record.url?scp=84975811144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975811144&partnerID=8YFLogxK

U2 - 10.1007/s11357-016-9925-y

DO - 10.1007/s11357-016-9925-y

M3 - Article

C2 - 27273077

AN - SCOPUS:84975811144

VL - 38

JO - GeroScience

JF - GeroScience

SN - 2509-2715

IS - 3

M1 - 64

ER -