Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III

Faith S. Luyster, Patrick J. Strollo, Fernando Holguin, Mario Castro, Eleanor M. Dunican, John Fahy, Benjamin Gaston, Elliot Israel, Nizar N. Jarjour, David Mauger, Wendy C. Moore, Sally E. Wenzel

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background Sleep difficulties are commonly reported by patients with asthma; however, the prevalence of insomnia and its association with disease burden and well-being is unknown. We aimed to determine the prevalence of insomnia, defined as combined sleep-specific complaints with associated daytime symptoms, among a large sample of adults with asthma, and to compare well-being, asthma control, and asthma-related health care utilization in individuals with asthma and insomnia and those without insomnia. Methods Baseline data from adults with physician-confirmed asthma enrolled in the Severe Asthma Research Program III was used for analyses (N = 714). Participants completed the Insomnia Severity Index (ISI), Asthma Control Test, Asthma Quality of Life Questionnaire, and Hospital Anxiety and Depression Scale. Results Insomnia (ISI ≥ 10) was identified in 263 participants (37%). Presence of insomnia was associated with higher levels of depression and anxiety symptoms and poorer quality of life. Those with insomnia had a 2.4-fold increased risk for having not well-controlled asthma and a 1.5-fold increased risk for asthma-related health care utilization in the past year compared with those without insomnia. Conclusions Insomnia is highly prevalent in asthma and is associated with adverse outcomes. Further studies are needed to gain a better understanding of the interaction between insomnia and asthma control.

Original languageEnglish (US)
Pages (from-to)1242-1250
Number of pages9
JournalCHEST
Volume150
Issue number6
DOIs
StatePublished - Dec 1 2016

Fingerprint

Sleep Initiation and Maintenance Disorders
Asthma
Research
Patient Acceptance of Health Care
Sleep
Anxiety
Quality of Life
Depression

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Luyster, F. S., Strollo, P. J., Holguin, F., Castro, M., Dunican, E. M., Fahy, J., ... Wenzel, S. E. (2016). Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III. CHEST, 150(6), 1242-1250. https://doi.org/10.1016/j.chest.2016.09.020
Luyster, Faith S. ; Strollo, Patrick J. ; Holguin, Fernando ; Castro, Mario ; Dunican, Eleanor M. ; Fahy, John ; Gaston, Benjamin ; Israel, Elliot ; Jarjour, Nizar N. ; Mauger, David ; Moore, Wendy C. ; Wenzel, Sally E. / Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III. In: CHEST. 2016 ; Vol. 150, No. 6. pp. 1242-1250.
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abstract = "Background Sleep difficulties are commonly reported by patients with asthma; however, the prevalence of insomnia and its association with disease burden and well-being is unknown. We aimed to determine the prevalence of insomnia, defined as combined sleep-specific complaints with associated daytime symptoms, among a large sample of adults with asthma, and to compare well-being, asthma control, and asthma-related health care utilization in individuals with asthma and insomnia and those without insomnia. Methods Baseline data from adults with physician-confirmed asthma enrolled in the Severe Asthma Research Program III was used for analyses (N = 714). Participants completed the Insomnia Severity Index (ISI), Asthma Control Test, Asthma Quality of Life Questionnaire, and Hospital Anxiety and Depression Scale. Results Insomnia (ISI ≥ 10) was identified in 263 participants (37{\%}). Presence of insomnia was associated with higher levels of depression and anxiety symptoms and poorer quality of life. Those with insomnia had a 2.4-fold increased risk for having not well-controlled asthma and a 1.5-fold increased risk for asthma-related health care utilization in the past year compared with those without insomnia. Conclusions Insomnia is highly prevalent in asthma and is associated with adverse outcomes. Further studies are needed to gain a better understanding of the interaction between insomnia and asthma control.",
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Luyster, FS, Strollo, PJ, Holguin, F, Castro, M, Dunican, EM, Fahy, J, Gaston, B, Israel, E, Jarjour, NN, Mauger, D, Moore, WC & Wenzel, SE 2016, 'Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III', CHEST, vol. 150, no. 6, pp. 1242-1250. https://doi.org/10.1016/j.chest.2016.09.020

Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III. / Luyster, Faith S.; Strollo, Patrick J.; Holguin, Fernando; Castro, Mario; Dunican, Eleanor M.; Fahy, John; Gaston, Benjamin; Israel, Elliot; Jarjour, Nizar N.; Mauger, David; Moore, Wendy C.; Wenzel, Sally E.

In: CHEST, Vol. 150, No. 6, 01.12.2016, p. 1242-1250.

Research output: Contribution to journalArticle

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AU - Luyster, Faith S.

AU - Strollo, Patrick J.

AU - Holguin, Fernando

AU - Castro, Mario

AU - Dunican, Eleanor M.

AU - Fahy, John

AU - Gaston, Benjamin

AU - Israel, Elliot

AU - Jarjour, Nizar N.

AU - Mauger, David

AU - Moore, Wendy C.

AU - Wenzel, Sally E.

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Y1 - 2016/12/1

N2 - Background Sleep difficulties are commonly reported by patients with asthma; however, the prevalence of insomnia and its association with disease burden and well-being is unknown. We aimed to determine the prevalence of insomnia, defined as combined sleep-specific complaints with associated daytime symptoms, among a large sample of adults with asthma, and to compare well-being, asthma control, and asthma-related health care utilization in individuals with asthma and insomnia and those without insomnia. Methods Baseline data from adults with physician-confirmed asthma enrolled in the Severe Asthma Research Program III was used for analyses (N = 714). Participants completed the Insomnia Severity Index (ISI), Asthma Control Test, Asthma Quality of Life Questionnaire, and Hospital Anxiety and Depression Scale. Results Insomnia (ISI ≥ 10) was identified in 263 participants (37%). Presence of insomnia was associated with higher levels of depression and anxiety symptoms and poorer quality of life. Those with insomnia had a 2.4-fold increased risk for having not well-controlled asthma and a 1.5-fold increased risk for asthma-related health care utilization in the past year compared with those without insomnia. Conclusions Insomnia is highly prevalent in asthma and is associated with adverse outcomes. Further studies are needed to gain a better understanding of the interaction between insomnia and asthma control.

AB - Background Sleep difficulties are commonly reported by patients with asthma; however, the prevalence of insomnia and its association with disease burden and well-being is unknown. We aimed to determine the prevalence of insomnia, defined as combined sleep-specific complaints with associated daytime symptoms, among a large sample of adults with asthma, and to compare well-being, asthma control, and asthma-related health care utilization in individuals with asthma and insomnia and those without insomnia. Methods Baseline data from adults with physician-confirmed asthma enrolled in the Severe Asthma Research Program III was used for analyses (N = 714). Participants completed the Insomnia Severity Index (ISI), Asthma Control Test, Asthma Quality of Life Questionnaire, and Hospital Anxiety and Depression Scale. Results Insomnia (ISI ≥ 10) was identified in 263 participants (37%). Presence of insomnia was associated with higher levels of depression and anxiety symptoms and poorer quality of life. Those with insomnia had a 2.4-fold increased risk for having not well-controlled asthma and a 1.5-fold increased risk for asthma-related health care utilization in the past year compared with those without insomnia. Conclusions Insomnia is highly prevalent in asthma and is associated with adverse outcomes. Further studies are needed to gain a better understanding of the interaction between insomnia and asthma control.

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Luyster FS, Strollo PJ, Holguin F, Castro M, Dunican EM, Fahy J et al. Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III. CHEST. 2016 Dec 1;150(6):1242-1250. https://doi.org/10.1016/j.chest.2016.09.020