Association between maternal urinary chromium and premature rupture of membranes in the Healthy Baby Cohort study in China

Sha Huang, Wei Xia, Yuanyuan Li, Bin Zhang, Aifen Zhou, Tongzhang Zheng, Zhengmin Qian, Zheng Huang, Shi Lu, Zhong Chen, Youjie Wang, Xinyun Pan, Wenqian Huo, Shuna Jin, Yangqian Jiang, Shunqing Xu

Research output: Contribution to journalArticle

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Abstract

Chromium exposure from increasing industrial releases has become a threat for pregnant women due to the potential health effects on vulnerable embryos. Previous studies have suggested that maternal chromium exposure is associated with adverse birth outcomes, but no epidemiological research has been conducted to examine the relationship between chromium exposure and premature rupture of membranes (PROM). This study aimed at investigating the association of maternal urinary chromium exposure levels with PROM and was performed with 5408 pregnant women recruited from 2012 to 2014 in the city of Wuhan, China. Maternal urinary chromium collected before labor was adjusted with creatinine, and its association with PROM was evaluated using logistic regression. Each one unit increase in the natural logarithm transformed maternal urinary chromium concentration (μg/g creatinine), an odds ratio (OR) of 1.47 [95% confidence interval (CI): 1.36, 1.58] for PROM was observed. Compared to the lowest tertile of maternal urinary chromium, PROM was positively correlated with increased urinary levels of chromium (adjusted OR = 1.42; 95% CI: 1.09, 1.84 for the medium tertile; adjusted OR = 2.77; 95% CI: 2.18, 3.52 for the highest tertile). Additionally, the association of chromium with PROM appeared to be more significant among male infants (adjusted OR = 3.52; 95% CI: 2.51, 4.94 for the highest tertile) than female infants (adjusted OR = 2.16; 95% CI: 1.52, 3.06 for the highest tertile) (p for interaction = 0.05). Our large birth cohort showed an association between maternal urinary chromium levels and PROM, and the association may differ by infant gender. Further studies from different populations are needed to confirm the observed association.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalEnvironmental Pollution
Volume230
DOIs
StatePublished - Jan 1 2017

Fingerprint

Chromium
Rupture
China
Cohort Studies
Mothers
Membranes
Odds Ratio
Confidence Intervals
Pregnant Women
Creatinine
Parturition
Maternal Exposure
Population Growth
Logistics
Embryonic Structures
Logistic Models
Health
Personnel

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Huang, Sha ; Xia, Wei ; Li, Yuanyuan ; Zhang, Bin ; Zhou, Aifen ; Zheng, Tongzhang ; Qian, Zhengmin ; Huang, Zheng ; Lu, Shi ; Chen, Zhong ; Wang, Youjie ; Pan, Xinyun ; Huo, Wenqian ; Jin, Shuna ; Jiang, Yangqian ; Xu, Shunqing. / Association between maternal urinary chromium and premature rupture of membranes in the Healthy Baby Cohort study in China. In: Environmental Pollution. 2017 ; Vol. 230. pp. 53-60.
@article{357b4e3419874560b2722764af5a70df,
title = "Association between maternal urinary chromium and premature rupture of membranes in the Healthy Baby Cohort study in China",
abstract = "Chromium exposure from increasing industrial releases has become a threat for pregnant women due to the potential health effects on vulnerable embryos. Previous studies have suggested that maternal chromium exposure is associated with adverse birth outcomes, but no epidemiological research has been conducted to examine the relationship between chromium exposure and premature rupture of membranes (PROM). This study aimed at investigating the association of maternal urinary chromium exposure levels with PROM and was performed with 5408 pregnant women recruited from 2012 to 2014 in the city of Wuhan, China. Maternal urinary chromium collected before labor was adjusted with creatinine, and its association with PROM was evaluated using logistic regression. Each one unit increase in the natural logarithm transformed maternal urinary chromium concentration (μg/g creatinine), an odds ratio (OR) of 1.47 [95{\%} confidence interval (CI): 1.36, 1.58] for PROM was observed. Compared to the lowest tertile of maternal urinary chromium, PROM was positively correlated with increased urinary levels of chromium (adjusted OR = 1.42; 95{\%} CI: 1.09, 1.84 for the medium tertile; adjusted OR = 2.77; 95{\%} CI: 2.18, 3.52 for the highest tertile). Additionally, the association of chromium with PROM appeared to be more significant among male infants (adjusted OR = 3.52; 95{\%} CI: 2.51, 4.94 for the highest tertile) than female infants (adjusted OR = 2.16; 95{\%} CI: 1.52, 3.06 for the highest tertile) (p for interaction = 0.05). Our large birth cohort showed an association between maternal urinary chromium levels and PROM, and the association may differ by infant gender. Further studies from different populations are needed to confirm the observed association.",
author = "Sha Huang and Wei Xia and Yuanyuan Li and Bin Zhang and Aifen Zhou and Tongzhang Zheng and Zhengmin Qian and Zheng Huang and Shi Lu and Zhong Chen and Youjie Wang and Xinyun Pan and Wenqian Huo and Shuna Jin and Yangqian Jiang and Shunqing Xu",
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Huang, S, Xia, W, Li, Y, Zhang, B, Zhou, A, Zheng, T, Qian, Z, Huang, Z, Lu, S, Chen, Z, Wang, Y, Pan, X, Huo, W, Jin, S, Jiang, Y & Xu, S 2017, 'Association between maternal urinary chromium and premature rupture of membranes in the Healthy Baby Cohort study in China', Environmental Pollution, vol. 230, pp. 53-60. https://doi.org/10.1016/j.envpol.2017.06.050

Association between maternal urinary chromium and premature rupture of membranes in the Healthy Baby Cohort study in China. / Huang, Sha; Xia, Wei; Li, Yuanyuan; Zhang, Bin; Zhou, Aifen; Zheng, Tongzhang; Qian, Zhengmin; Huang, Zheng; Lu, Shi; Chen, Zhong; Wang, Youjie; Pan, Xinyun; Huo, Wenqian; Jin, Shuna; Jiang, Yangqian; Xu, Shunqing.

In: Environmental Pollution, Vol. 230, 01.01.2017, p. 53-60.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between maternal urinary chromium and premature rupture of membranes in the Healthy Baby Cohort study in China

AU - Huang, Sha

AU - Xia, Wei

AU - Li, Yuanyuan

AU - Zhang, Bin

AU - Zhou, Aifen

AU - Zheng, Tongzhang

AU - Qian, Zhengmin

AU - Huang, Zheng

AU - Lu, Shi

AU - Chen, Zhong

AU - Wang, Youjie

AU - Pan, Xinyun

AU - Huo, Wenqian

AU - Jin, Shuna

AU - Jiang, Yangqian

AU - Xu, Shunqing

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Chromium exposure from increasing industrial releases has become a threat for pregnant women due to the potential health effects on vulnerable embryos. Previous studies have suggested that maternal chromium exposure is associated with adverse birth outcomes, but no epidemiological research has been conducted to examine the relationship between chromium exposure and premature rupture of membranes (PROM). This study aimed at investigating the association of maternal urinary chromium exposure levels with PROM and was performed with 5408 pregnant women recruited from 2012 to 2014 in the city of Wuhan, China. Maternal urinary chromium collected before labor was adjusted with creatinine, and its association with PROM was evaluated using logistic regression. Each one unit increase in the natural logarithm transformed maternal urinary chromium concentration (μg/g creatinine), an odds ratio (OR) of 1.47 [95% confidence interval (CI): 1.36, 1.58] for PROM was observed. Compared to the lowest tertile of maternal urinary chromium, PROM was positively correlated with increased urinary levels of chromium (adjusted OR = 1.42; 95% CI: 1.09, 1.84 for the medium tertile; adjusted OR = 2.77; 95% CI: 2.18, 3.52 for the highest tertile). Additionally, the association of chromium with PROM appeared to be more significant among male infants (adjusted OR = 3.52; 95% CI: 2.51, 4.94 for the highest tertile) than female infants (adjusted OR = 2.16; 95% CI: 1.52, 3.06 for the highest tertile) (p for interaction = 0.05). Our large birth cohort showed an association between maternal urinary chromium levels and PROM, and the association may differ by infant gender. Further studies from different populations are needed to confirm the observed association.

AB - Chromium exposure from increasing industrial releases has become a threat for pregnant women due to the potential health effects on vulnerable embryos. Previous studies have suggested that maternal chromium exposure is associated with adverse birth outcomes, but no epidemiological research has been conducted to examine the relationship between chromium exposure and premature rupture of membranes (PROM). This study aimed at investigating the association of maternal urinary chromium exposure levels with PROM and was performed with 5408 pregnant women recruited from 2012 to 2014 in the city of Wuhan, China. Maternal urinary chromium collected before labor was adjusted with creatinine, and its association with PROM was evaluated using logistic regression. Each one unit increase in the natural logarithm transformed maternal urinary chromium concentration (μg/g creatinine), an odds ratio (OR) of 1.47 [95% confidence interval (CI): 1.36, 1.58] for PROM was observed. Compared to the lowest tertile of maternal urinary chromium, PROM was positively correlated with increased urinary levels of chromium (adjusted OR = 1.42; 95% CI: 1.09, 1.84 for the medium tertile; adjusted OR = 2.77; 95% CI: 2.18, 3.52 for the highest tertile). Additionally, the association of chromium with PROM appeared to be more significant among male infants (adjusted OR = 3.52; 95% CI: 2.51, 4.94 for the highest tertile) than female infants (adjusted OR = 2.16; 95% CI: 1.52, 3.06 for the highest tertile) (p for interaction = 0.05). Our large birth cohort showed an association between maternal urinary chromium levels and PROM, and the association may differ by infant gender. Further studies from different populations are needed to confirm the observed association.

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