Association between prediagnostic biomarkers of inflammation and endothelial function and cancer risk: A nested case-control study

Mathilde Touvier, Léopold Fezeu, Namanjeet Ahluwalia, Chantal Julia, Nathalie Charnaux, Angela Sutton, Caroline Méjean, Paule Latino-Martel, Serge Hercberg, Pilar Galan, Sébastien Czernichow

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Abstract

Experimental and prevalent case-control studies suggest an association between biomarkers of inflammation, endothelial function, and adiposity and cancer risk, but results from prospective studies have been limited. The authors' objective was to prospectively examine the relations between these biomarkers and cancer risk. A nested case-control study was designed within the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) Study, a nationwide French cohort study, to include all first primary incident cancers diagnosed between 1994 and 2007 (n = 512). Cases were matched with randomly selected controls (n = 1,024) on sex, age (in 2-year strata), body mass index (weight (kg)/height (m)2; <25 vs. ≥25), and SU.VI.MAX intervention group. Conditional logistic regression was used to study the associations between prediagnostic levels of high-sensitivity C-reactive protein (hs-CRP), adiponectin, leptin, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1, soluble E-selectin, and monocyte chemoattractant protein 1 and cancer risk. All statistical tests were 2-sided. Plasma sICAM-1 level was positively associated with breast cancer risk (for quartile 4 vs. quartile 1, multivariate odds ratio (OR) = 1.86, 95% confidence interval (CI): 1.06, 3.26; Ptrend = 0.048). Plasma hs-CRP level was positively associated with prostate cancer risk (for quartile 4 vs. quartile 1, multivariate OR = 3.04, 95% CI: 1.28, 7.23; Ptrend = 0.03). These results suggest that prediagnostic hs-CRP and sICAM-1 levels are associated with increased prostate and breast cancer risk, respectively.

Original languageEnglish (US)
Pages (from-to)3-13
Number of pages11
JournalAmerican journal of epidemiology
Volume177
Issue number1
DOIs
StatePublished - Jan 1 2013

All Science Journal Classification (ASJC) codes

  • Epidemiology

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    Touvier, M., Fezeu, L., Ahluwalia, N., Julia, C., Charnaux, N., Sutton, A., Méjean, C., Latino-Martel, P., Hercberg, S., Galan, P., & Czernichow, S. (2013). Association between prediagnostic biomarkers of inflammation and endothelial function and cancer risk: A nested case-control study. American journal of epidemiology, 177(1), 3-13. https://doi.org/10.1093/aje/kws359