Association between sleep duration, insomnia symptoms and bone mineral density in older boston puerto rican adults

Jinya Niu, Shivani Sahni, Susu Liao, Katherine L. Tucker, Bess Dawson-Hughes, Xiang Gao

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective To examine the association between sleep patterns (sleep duration and insomnia symptoms) and total and regional bone mineral density (BMD) among older Boston Puerto Rican adults. Materials/Methods We conducted a cross-sectional study including 750 Puerto Rican adults, aged 47-79 y living in Massachusetts. BMD at 3 hip sites and the lumbar spine were measured using dualenergy X-ray absorptiometry. Sleep duration ([[amp]]le;5 h, 6 h, 7 h, 8 h, or [[amp]]ge; 9 h/d) and insomnia symptoms (difficulty initiating sleep, difficulty maintaining sleep, early-morning awaking, and non-restorative sleep) were assessed by a questionnaire. Multivariable regression was used to examine sex-specific associations between sleep duration, insomnia symptoms and BMD adjusting for standard confounders and covariates. Results Men who slept [[amp]]ge;9h/d had significantly lower femoral neck BMD, relative to those reporting8 h/d sleep, after adjusting for age, education level, smoking, physical activity, depressive symptomatology, comorbidity and serum vitamin D concentration. This association was attenuated and lost significance after further adjustment for urinary cortisol and serum inflammation biomarkers. In contrast, the association between sleep duration and BMD was not significant in women. Further, we did not find any significant associations between insomnia symptoms and BMD in men or women. Conclusions Our study does not support the hypothesis that shorter sleep duration and insomnia symptoms are associated with lower BMD levels in older adults. However, our results should be interpreted with caution. Future studies with larger sample size, objective assessment of sleep pattern, and prospective design are needed before a conclusion regarding sleep and BMD can be reached.

Original languageEnglish (US)
Article number0132342
JournalPloS one
Volume10
Issue number7
DOIs
StatePublished - Jul 6 2015

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bone density
Sleep Initiation and Maintenance Disorders
sleep
Bone Density
signs and symptoms (animals and humans)
Minerals
Sleep
Bone
duration
Association reactions
Hispanic Americans
sleep disorders
lumbar spine
Femur Neck
Photon Absorptiometry
Serum
educational status
Biomarkers
thighs
Vitamin D

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Niu, Jinya ; Sahni, Shivani ; Liao, Susu ; Tucker, Katherine L. ; Dawson-Hughes, Bess ; Gao, Xiang. / Association between sleep duration, insomnia symptoms and bone mineral density in older boston puerto rican adults. In: PloS one. 2015 ; Vol. 10, No. 7.
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abstract = "Objective To examine the association between sleep patterns (sleep duration and insomnia symptoms) and total and regional bone mineral density (BMD) among older Boston Puerto Rican adults. Materials/Methods We conducted a cross-sectional study including 750 Puerto Rican adults, aged 47-79 y living in Massachusetts. BMD at 3 hip sites and the lumbar spine were measured using dualenergy X-ray absorptiometry. Sleep duration ([[amp]]le;5 h, 6 h, 7 h, 8 h, or [[amp]]ge; 9 h/d) and insomnia symptoms (difficulty initiating sleep, difficulty maintaining sleep, early-morning awaking, and non-restorative sleep) were assessed by a questionnaire. Multivariable regression was used to examine sex-specific associations between sleep duration, insomnia symptoms and BMD adjusting for standard confounders and covariates. Results Men who slept [[amp]]ge;9h/d had significantly lower femoral neck BMD, relative to those reporting8 h/d sleep, after adjusting for age, education level, smoking, physical activity, depressive symptomatology, comorbidity and serum vitamin D concentration. This association was attenuated and lost significance after further adjustment for urinary cortisol and serum inflammation biomarkers. In contrast, the association between sleep duration and BMD was not significant in women. Further, we did not find any significant associations between insomnia symptoms and BMD in men or women. Conclusions Our study does not support the hypothesis that shorter sleep duration and insomnia symptoms are associated with lower BMD levels in older adults. However, our results should be interpreted with caution. Future studies with larger sample size, objective assessment of sleep pattern, and prospective design are needed before a conclusion regarding sleep and BMD can be reached.",
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Association between sleep duration, insomnia symptoms and bone mineral density in older boston puerto rican adults. / Niu, Jinya; Sahni, Shivani; Liao, Susu; Tucker, Katherine L.; Dawson-Hughes, Bess; Gao, Xiang.

In: PloS one, Vol. 10, No. 7, 0132342, 06.07.2015.

Research output: Contribution to journalArticle

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