Association between systemic inflammatory markers and serum prostate-specific antigen in men without prostatic disease - The 2001-2008 National Health and Nutrition examination survey

Alicia C. McDonald, Manish A. Vira, Adriana C. Vidal, Wenqi Gan, Stephen J. Freedland, Emanuela Taioli

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Serum prostate specific antigen (PSA) may be elevated in otherwise healthy men; systemic inflammation has been associated with cancer. The study of systemic inflammatory markers in men without clinical prostate disease, but with elevated PSA may characterize the subgroup of men at higher risk for subsequent prostate cancer. METHODS We investigated the associations between systemic inflammatory markers and serum PSA in 3,164 healthy men without prostatic disease, aged >40 years, from the 2001 to 2008 U.S. National Health and Nutrition Examination Survey (NHANES). Serum total PSA levels and concentrations of serum C-reactive protein (CRP) and plasma fibrinogen, neutrophil count, lymphocyte count, and platelet count were recorded. Neutrophil-lymphocyte ratio (NLR) ratio and platelet-lymphocyte (PLR) ratio were calculated. PSA elevation was defined as levels equal or greater than 4 ng/ml. RESULTS Elevated serum PSA (194 men, 6.1% of the total), was significantly associated with plasma fibrinogen (ORmultiv = 1.88; 95% CI, 1.09-3.25), and NLR (OR multiv = 1.14; 95% CI, 1.03-1.26), after adjustment for age, smoking, body mass index, education, race, co-morbidities, and use of medications. CONCLUSIONS Markers of systemic inflammation were associated with elevated PSA in men without known prostatic disease. Future studies are needed to examine these markers' relationship with prostate cancer occurrence and progression. Prostate 74:561-567, 2014.

Original languageEnglish (US)
Pages (from-to)561-567
Number of pages7
JournalProstate
Volume74
Issue number5
DOIs
StatePublished - May 1 2014

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Prostatic Diseases
Nutrition Surveys
Prostate-Specific Antigen
Biomarkers
Neutrophils
Lymphocytes
Fibrinogen
Prostate
Prostatic Neoplasms
Serum
Inflammation
Lymphocyte Count
Platelet Count
C-Reactive Protein
Blood Proteins
Body Mass Index
Blood Platelets
Smoking
Morbidity
Education

All Science Journal Classification (ASJC) codes

  • Oncology
  • Urology

Cite this

McDonald, Alicia C. ; Vira, Manish A. ; Vidal, Adriana C. ; Gan, Wenqi ; Freedland, Stephen J. ; Taioli, Emanuela. / Association between systemic inflammatory markers and serum prostate-specific antigen in men without prostatic disease - The 2001-2008 National Health and Nutrition examination survey. In: Prostate. 2014 ; Vol. 74, No. 5. pp. 561-567.
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abstract = "Serum prostate specific antigen (PSA) may be elevated in otherwise healthy men; systemic inflammation has been associated with cancer. The study of systemic inflammatory markers in men without clinical prostate disease, but with elevated PSA may characterize the subgroup of men at higher risk for subsequent prostate cancer. METHODS We investigated the associations between systemic inflammatory markers and serum PSA in 3,164 healthy men without prostatic disease, aged >40 years, from the 2001 to 2008 U.S. National Health and Nutrition Examination Survey (NHANES). Serum total PSA levels and concentrations of serum C-reactive protein (CRP) and plasma fibrinogen, neutrophil count, lymphocyte count, and platelet count were recorded. Neutrophil-lymphocyte ratio (NLR) ratio and platelet-lymphocyte (PLR) ratio were calculated. PSA elevation was defined as levels equal or greater than 4 ng/ml. RESULTS Elevated serum PSA (194 men, 6.1{\%} of the total), was significantly associated with plasma fibrinogen (ORmultiv = 1.88; 95{\%} CI, 1.09-3.25), and NLR (OR multiv = 1.14; 95{\%} CI, 1.03-1.26), after adjustment for age, smoking, body mass index, education, race, co-morbidities, and use of medications. CONCLUSIONS Markers of systemic inflammation were associated with elevated PSA in men without known prostatic disease. Future studies are needed to examine these markers' relationship with prostate cancer occurrence and progression. Prostate 74:561-567, 2014.",
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Association between systemic inflammatory markers and serum prostate-specific antigen in men without prostatic disease - The 2001-2008 National Health and Nutrition examination survey. / McDonald, Alicia C.; Vira, Manish A.; Vidal, Adriana C.; Gan, Wenqi; Freedland, Stephen J.; Taioli, Emanuela.

In: Prostate, Vol. 74, No. 5, 01.05.2014, p. 561-567.

Research output: Contribution to journalArticle

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N2 - Serum prostate specific antigen (PSA) may be elevated in otherwise healthy men; systemic inflammation has been associated with cancer. The study of systemic inflammatory markers in men without clinical prostate disease, but with elevated PSA may characterize the subgroup of men at higher risk for subsequent prostate cancer. METHODS We investigated the associations between systemic inflammatory markers and serum PSA in 3,164 healthy men without prostatic disease, aged >40 years, from the 2001 to 2008 U.S. National Health and Nutrition Examination Survey (NHANES). Serum total PSA levels and concentrations of serum C-reactive protein (CRP) and plasma fibrinogen, neutrophil count, lymphocyte count, and platelet count were recorded. Neutrophil-lymphocyte ratio (NLR) ratio and platelet-lymphocyte (PLR) ratio were calculated. PSA elevation was defined as levels equal or greater than 4 ng/ml. RESULTS Elevated serum PSA (194 men, 6.1% of the total), was significantly associated with plasma fibrinogen (ORmultiv = 1.88; 95% CI, 1.09-3.25), and NLR (OR multiv = 1.14; 95% CI, 1.03-1.26), after adjustment for age, smoking, body mass index, education, race, co-morbidities, and use of medications. CONCLUSIONS Markers of systemic inflammation were associated with elevated PSA in men without known prostatic disease. Future studies are needed to examine these markers' relationship with prostate cancer occurrence and progression. Prostate 74:561-567, 2014.

AB - Serum prostate specific antigen (PSA) may be elevated in otherwise healthy men; systemic inflammation has been associated with cancer. The study of systemic inflammatory markers in men without clinical prostate disease, but with elevated PSA may characterize the subgroup of men at higher risk for subsequent prostate cancer. METHODS We investigated the associations between systemic inflammatory markers and serum PSA in 3,164 healthy men without prostatic disease, aged >40 years, from the 2001 to 2008 U.S. National Health and Nutrition Examination Survey (NHANES). Serum total PSA levels and concentrations of serum C-reactive protein (CRP) and plasma fibrinogen, neutrophil count, lymphocyte count, and platelet count were recorded. Neutrophil-lymphocyte ratio (NLR) ratio and platelet-lymphocyte (PLR) ratio were calculated. PSA elevation was defined as levels equal or greater than 4 ng/ml. RESULTS Elevated serum PSA (194 men, 6.1% of the total), was significantly associated with plasma fibrinogen (ORmultiv = 1.88; 95% CI, 1.09-3.25), and NLR (OR multiv = 1.14; 95% CI, 1.03-1.26), after adjustment for age, smoking, body mass index, education, race, co-morbidities, and use of medications. CONCLUSIONS Markers of systemic inflammation were associated with elevated PSA in men without known prostatic disease. Future studies are needed to examine these markers' relationship with prostate cancer occurrence and progression. Prostate 74:561-567, 2014.

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