Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease

Frederick P. Siegal, Ruth Voss, Hamid Al-Mondhiry, Aaron Polliack, John A. Hansen, Marta Siegal, Robert A. Good

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.

Original languageEnglish (US)
Pages (from-to)157-166
Number of pages10
JournalUnknown Journal
Volume60
Issue number1
DOIs
StatePublished - Jan 1 1976

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Chromosome Aberrations
B-Lymphocytes
Erythrocytes
Lymphocytes
Genetic Markers
Non-Hodgkin's Lymphoma
Sheep
T-Lymphocytes
Phenotype

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Siegal, F. P., Voss, R., Al-Mondhiry, H., Polliack, A., Hansen, J. A., Siegal, M., & Good, R. A. (1976). Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease. Unknown Journal, 60(1), 157-166. https://doi.org/10.1016/0002-9343(76)90559-3
Siegal, Frederick P. ; Voss, Ruth ; Al-Mondhiry, Hamid ; Polliack, Aaron ; Hansen, John A. ; Siegal, Marta ; Good, Robert A. / Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease. In: Unknown Journal. 1976 ; Vol. 60, No. 1. pp. 157-166.
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Siegal, FP, Voss, R, Al-Mondhiry, H, Polliack, A, Hansen, JA, Siegal, M & Good, RA 1976, 'Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease', Unknown Journal, vol. 60, no. 1, pp. 157-166. https://doi.org/10.1016/0002-9343(76)90559-3

Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease. / Siegal, Frederick P.; Voss, Ruth; Al-Mondhiry, Hamid; Polliack, Aaron; Hansen, John A.; Siegal, Marta; Good, Robert A.

In: Unknown Journal, Vol. 60, No. 1, 01.01.1976, p. 157-166.

Research output: Contribution to journal › Article

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AU - Hansen, John A.

AU - Siegal, Marta

AU - Good, Robert A.

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AB - The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.

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Siegal FP, Voss R, Al-Mondhiry H, Polliack A, Hansen JA, Siegal M et al. Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease. Unknown Journal. 1976 Jan 1;60(1):157-166. https://doi.org/10.1016/0002-9343(76)90559-3

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