Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease

Frederick P. Siegal; Ruth Voss; Hamid Al-Mondhiry; Aaron Polliack; John A. Hansen; Marta Siegal; Robert A. Good

doi:10.1016/0002-9343(76)90559-3

Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease

Frederick P. Siegal, Ruth Voss, Hamid Al-Mondhiry, Aaron Polliack, John A. Hansen, Marta Siegal, Robert A. Good

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.

Original language	English (US)
Pages (from-to)	157-166
Number of pages	10
Journal	Unknown Journal
Volume	60
Issue number	1
DOIs	https://doi.org/10.1016/0002-9343(76)90559-3
State	Published - Jan 1 1976

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1016/0002-9343(76)90559-3

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title = "Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease",

abstract = "The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.",

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Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease. / Siegal, Frederick P.; Voss, Ruth; Al-Mondhiry, Hamid; Polliack, Aaron; Hansen, John A.; Siegal, Marta; Good, Robert A.

In: Unknown Journal, Vol. 60, No. 1, 01.01.1976, p. 157-166.

Research output: Contribution to journal › Article › peer-review

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T1 - Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease

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AU - Voss, Ruth

AU - Al-Mondhiry, Hamid

AU - Polliack, Aaron

AU - Hansen, John A.

AU - Siegal, Marta

AU - Good, Robert A.

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AB - The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.

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