Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease

Frederick P. Siegal, Ruth Voss, Hamid Al-Mondhiry, Aaron Polliack, John A. Hansen, Marta Siegal, Robert A. Good

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Abstract

The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement-coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.

Original languageEnglish (US)
Pages (from-to)157-166
Number of pages10
JournalThe American journal of medicine
Volume60
Issue number1
DOIs
Publication statusPublished - Jan 1 1976

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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