Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease

Frederick P. Siegal, Ruth Voss, Hamid Al-Mondhiry, Aaron Polliack, John A. Hansen, Marta Siegal, Robert A. Good

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The lymphocytes of a patient with leukemic lymphosarcoma were found to have an unusual surface phenotype in that they bound both sheep erythrocytes (a T cell marker) and complement-coated erythrocytes (a B cell marker) but lacked other B cell surface characteristics. Marker chromosomes were present in these cells, but not in other, phenotypically normal cells from the same patient. This case may provide a clue to the chromosomal origin of some lymphocyte surface markers in man.

Original languageEnglish (US)
Pages (from-to)157-166
Number of pages10
JournalThe American journal of medicine
Volume60
Issue number1
DOIs
StatePublished - Jan 1 1976

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Chromosome Aberrations
B-Lymphocytes
Erythrocytes
Lymphocytes
Genetic Markers
Non-Hodgkin's Lymphoma
Sheep
T-Lymphocytes
Phenotype

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Siegal, Frederick P. ; Voss, Ruth ; Al-Mondhiry, Hamid ; Polliack, Aaron ; Hansen, John A. ; Siegal, Marta ; Good, Robert A. / Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease. In: The American journal of medicine. 1976 ; Vol. 60, No. 1. pp. 157-166.
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Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease. / Siegal, Frederick P.; Voss, Ruth; Al-Mondhiry, Hamid; Polliack, Aaron; Hansen, John A.; Siegal, Marta; Good, Robert A.

In: The American journal of medicine, Vol. 60, No. 1, 01.01.1976, p. 157-166.

Research output: Contribution to journalArticle

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