Association of a low density lipoprotein receptor microsatellite variant with obesity

S. Rutherford, D. R. Nyholt, R. P. Curtain, S. R. Quinlan, P. T. Gaffney, B. J. Morris, L. R. Griffiths

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Abstract

OBJECTIVE: To determine whether a microsatellite polymorphism located towards the 3' end of the low density lipoprotein receptor gene (LDLR) is associated with obesity. DESIGN: A cross-sectional case-control study. SUBJECTS: One hundred and seven obese individuals, defined as a body mass index (BMI) ≤ 26 kg/m2, and 163 lean individuals, defined as a BMI < 26 kg/m2. MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp). RESULTS: There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (χ2 = 12.3, P = 0.002), but not in males (χ2 = 0.3, P = 0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese. CONCLUSIONS: These results suggest that in females, LDLR may play a role in the development of obesity.

Original languageEnglish (US)
Pages (from-to)1032-1037
Number of pages6
JournalInternational Journal of Obesity
Volume21
Issue number11
DOIs
StatePublished - Jan 1 1997

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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    Rutherford, S., Nyholt, D. R., Curtain, R. P., Quinlan, S. R., Gaffney, P. T., Morris, B. J., & Griffiths, L. R. (1997). Association of a low density lipoprotein receptor microsatellite variant with obesity. International Journal of Obesity, 21(11), 1032-1037. https://doi.org/10.1038/sj.ijo.0800512