Association of Active and Sedentary Behaviors with Postmenopausal Estrogen Metabolism

Cher M. Dallal, Louise A. Brinton, Charles E. Matthews, Ruth M. Pfeiffer, Terryl Johnson Hartman, Jolanta Lissowska, Roni T. Falk, Montserrat Garcia-Closas, Xia Xu, Timothy D. Veenstra, Gretchen L. Gierach

Research output: Contribution to journalArticle

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Abstract

Purpose Physical activity may reduce endogenous estrogens, but few studies have assessed effects on estrogen metabolism and none have evaluated sedentary behavior in relation to estrogen metabolism. We assessed relationships between accelerometer-measured physical activity and sedentary behavior and 15 urinary estrogens and estrogen metabolites (EM) among postmenopausal controls from a population-based breast cancer case-control study conducted in Poland (2000-2003). Methods Postmenopausal women (N = 542) were ages 40 to 72 yr and not currently using hormone therapy. Accelerometers, worn for 7 d, were used to derive measures of average activity (counts per day) and sedentary behavior (<100 counts per minute per day). Estrogen metabolites were measured in 12-h urine samples using liquid chromatography-tandem mass spectrometry. Estrogen metabolites were analyzed individually, in metabolic pathways (C-2,-4, or-16), and as ratios relative to parent estrogens. Geometric means of estrogen metabolites by tertiles of accelerometer-measures, adjusted for age and body mass, were computed using linear models. Results High activity was associated with lower levels of estrone and estradiol (P trend = 0.01), whereas increased sedentary time was positively associated with these parent estrogens (P trend = 0.04). Inverse associations were observed between high activity and 2-methoxyestradiol, 4-methoxyestradiol, 17-epiestriol, and 16-epiestriol (P trend = 0.03). Sedentary time was positively associated with methylated catechols in the 2-and 4-hydroxylation pathways (P trend ≤ 0.04). Women in the highest tertile of activity had increased hydroxylation at the C-2,-4, and-16 sites relative to parent estrogens (P trend ≤ 0.02), whereas increased sedentary time was associated with a lower 16-pathway/parent estrogen ratio (P trend = 0.01). Conclusions Higher activity was associated with lower urinary estrogens, possibly through increased estrogen hydroxylation and infsequent metabolism, whereas sedentary behavior may reduce metabolism.

Original languageEnglish (US)
Pages (from-to)439-448
Number of pages10
JournalMedicine and Science in Sports and Exercise
Volume48
Issue number3
DOIs
StatePublished - Mar 1 2016

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Estrogens
Hydroxylation
Estriol
Catechols
Exercise
Estrone
Poland
Tandem Mass Spectrometry
Metabolic Networks and Pathways
Liquid Chromatography
Case-Control Studies
Estradiol
Linear Models
Urine
Hormones
Breast Neoplasms

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Dallal, C. M., Brinton, L. A., Matthews, C. E., Pfeiffer, R. M., Hartman, T. J., Lissowska, J., ... Gierach, G. L. (2016). Association of Active and Sedentary Behaviors with Postmenopausal Estrogen Metabolism. Medicine and Science in Sports and Exercise, 48(3), 439-448. https://doi.org/10.1249/MSS.0000000000000790
Dallal, Cher M. ; Brinton, Louise A. ; Matthews, Charles E. ; Pfeiffer, Ruth M. ; Hartman, Terryl Johnson ; Lissowska, Jolanta ; Falk, Roni T. ; Garcia-Closas, Montserrat ; Xu, Xia ; Veenstra, Timothy D. ; Gierach, Gretchen L. / Association of Active and Sedentary Behaviors with Postmenopausal Estrogen Metabolism. In: Medicine and Science in Sports and Exercise. 2016 ; Vol. 48, No. 3. pp. 439-448.
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Dallal, CM, Brinton, LA, Matthews, CE, Pfeiffer, RM, Hartman, TJ, Lissowska, J, Falk, RT, Garcia-Closas, M, Xu, X, Veenstra, TD & Gierach, GL 2016, 'Association of Active and Sedentary Behaviors with Postmenopausal Estrogen Metabolism', Medicine and Science in Sports and Exercise, vol. 48, no. 3, pp. 439-448. https://doi.org/10.1249/MSS.0000000000000790

Association of Active and Sedentary Behaviors with Postmenopausal Estrogen Metabolism. / Dallal, Cher M.; Brinton, Louise A.; Matthews, Charles E.; Pfeiffer, Ruth M.; Hartman, Terryl Johnson; Lissowska, Jolanta; Falk, Roni T.; Garcia-Closas, Montserrat; Xu, Xia; Veenstra, Timothy D.; Gierach, Gretchen L.

In: Medicine and Science in Sports and Exercise, Vol. 48, No. 3, 01.03.2016, p. 439-448.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of Active and Sedentary Behaviors with Postmenopausal Estrogen Metabolism

AU - Dallal, Cher M.

AU - Brinton, Louise A.

AU - Matthews, Charles E.

AU - Pfeiffer, Ruth M.

AU - Hartman, Terryl Johnson

AU - Lissowska, Jolanta

AU - Falk, Roni T.

AU - Garcia-Closas, Montserrat

AU - Xu, Xia

AU - Veenstra, Timothy D.

AU - Gierach, Gretchen L.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Purpose Physical activity may reduce endogenous estrogens, but few studies have assessed effects on estrogen metabolism and none have evaluated sedentary behavior in relation to estrogen metabolism. We assessed relationships between accelerometer-measured physical activity and sedentary behavior and 15 urinary estrogens and estrogen metabolites (EM) among postmenopausal controls from a population-based breast cancer case-control study conducted in Poland (2000-2003). Methods Postmenopausal women (N = 542) were ages 40 to 72 yr and not currently using hormone therapy. Accelerometers, worn for 7 d, were used to derive measures of average activity (counts per day) and sedentary behavior (<100 counts per minute per day). Estrogen metabolites were measured in 12-h urine samples using liquid chromatography-tandem mass spectrometry. Estrogen metabolites were analyzed individually, in metabolic pathways (C-2,-4, or-16), and as ratios relative to parent estrogens. Geometric means of estrogen metabolites by tertiles of accelerometer-measures, adjusted for age and body mass, were computed using linear models. Results High activity was associated with lower levels of estrone and estradiol (P trend = 0.01), whereas increased sedentary time was positively associated with these parent estrogens (P trend = 0.04). Inverse associations were observed between high activity and 2-methoxyestradiol, 4-methoxyestradiol, 17-epiestriol, and 16-epiestriol (P trend = 0.03). Sedentary time was positively associated with methylated catechols in the 2-and 4-hydroxylation pathways (P trend ≤ 0.04). Women in the highest tertile of activity had increased hydroxylation at the C-2,-4, and-16 sites relative to parent estrogens (P trend ≤ 0.02), whereas increased sedentary time was associated with a lower 16-pathway/parent estrogen ratio (P trend = 0.01). Conclusions Higher activity was associated with lower urinary estrogens, possibly through increased estrogen hydroxylation and infsequent metabolism, whereas sedentary behavior may reduce metabolism.

AB - Purpose Physical activity may reduce endogenous estrogens, but few studies have assessed effects on estrogen metabolism and none have evaluated sedentary behavior in relation to estrogen metabolism. We assessed relationships between accelerometer-measured physical activity and sedentary behavior and 15 urinary estrogens and estrogen metabolites (EM) among postmenopausal controls from a population-based breast cancer case-control study conducted in Poland (2000-2003). Methods Postmenopausal women (N = 542) were ages 40 to 72 yr and not currently using hormone therapy. Accelerometers, worn for 7 d, were used to derive measures of average activity (counts per day) and sedentary behavior (<100 counts per minute per day). Estrogen metabolites were measured in 12-h urine samples using liquid chromatography-tandem mass spectrometry. Estrogen metabolites were analyzed individually, in metabolic pathways (C-2,-4, or-16), and as ratios relative to parent estrogens. Geometric means of estrogen metabolites by tertiles of accelerometer-measures, adjusted for age and body mass, were computed using linear models. Results High activity was associated with lower levels of estrone and estradiol (P trend = 0.01), whereas increased sedentary time was positively associated with these parent estrogens (P trend = 0.04). Inverse associations were observed between high activity and 2-methoxyestradiol, 4-methoxyestradiol, 17-epiestriol, and 16-epiestriol (P trend = 0.03). Sedentary time was positively associated with methylated catechols in the 2-and 4-hydroxylation pathways (P trend ≤ 0.04). Women in the highest tertile of activity had increased hydroxylation at the C-2,-4, and-16 sites relative to parent estrogens (P trend ≤ 0.02), whereas increased sedentary time was associated with a lower 16-pathway/parent estrogen ratio (P trend = 0.01). Conclusions Higher activity was associated with lower urinary estrogens, possibly through increased estrogen hydroxylation and infsequent metabolism, whereas sedentary behavior may reduce metabolism.

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