Association of DRD4 with attention problems in normal childhood development

Louis A. Schmidt, Nathan A. Fox, Koraly Perez-Edgar, Stella Hu, Dean H. Hamer

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Several previous studies found an association of clinically diagnosed attention deficit hyperactivity disorder with long alleles of a variation in the DRD4 dopamine receptor gene exon III coding sequence. We evaluated the DRD4 polymorphism in a non-clinically selected sample of children for whom maternal reports of attention problems were available at 4 and 7 years of age. There was a significant elevation in attention problem scores in children carrying DRD4 long alleles that accounted for 3-4% of total variation at each age and for 5-7% of the temporally stable component of the phenotype. Our results show that the DRD4 gene influences normal as well as pathological attention processes, and the results highlight the utility of longitudinal measurements in psychiatric genetics.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalPsychiatric Genetics
Volume11
Issue number1
DOIs
StatePublished - Jun 13 2001

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Alleles
Dopamine Receptors
Pathologic Processes
Attention Deficit Disorder with Hyperactivity
Genes
Psychiatry
Exons
Mothers
Phenotype

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Schmidt, Louis A. ; Fox, Nathan A. ; Perez-Edgar, Koraly ; Hu, Stella ; Hamer, Dean H. / Association of DRD4 with attention problems in normal childhood development. In: Psychiatric Genetics. 2001 ; Vol. 11, No. 1. pp. 25-29.
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Association of DRD4 with attention problems in normal childhood development. / Schmidt, Louis A.; Fox, Nathan A.; Perez-Edgar, Koraly; Hu, Stella; Hamer, Dean H.

In: Psychiatric Genetics, Vol. 11, No. 1, 13.06.2001, p. 25-29.

Research output: Contribution to journalArticle

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