Association of endothelial nitric oxide synthase gene G894T polymorphism with essential hypertension in an adult Pakistani Pathan population

Muhammad Rizwanulhaq Khawaja, Fawad Taj, Usman Ahmad, Danish Saleheen, Tazeen Jafar, Philippe M. Frossard

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13 Citations (Scopus)

Abstract

This retrospective, case-control study was carried out to find putative correlations of eNOS G894T polymorphism with essential hypertension (EHT) amongst adult Pakistani Pathans. We investigated a sample population of 332 (154 men, 178 women) comprising groups of 146 hypertensives (HTs) and 186 normotensives (NTs) by assays based on polymerase chain reaction followed by restriction endonuclease analysis. The distribution of the genotypes or alleles was not statistically different in hypertensive and normotensive groups. In conclusion, the present study in a population of Pakistani adult Pathans does not support the association of the eNOS gene G894T polymorphism to essential hypertension.

Original languageEnglish (US)
Pages (from-to)113-115
Number of pages3
JournalInternational Journal of Cardiology
Volume116
Issue number1
DOIs
StatePublished - Mar 2 2007

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Nitric Oxide Synthase Type III
DNA Restriction Enzymes
Population
Genes
Case-Control Studies
Alleles
Genotype
Polymerase Chain Reaction
Essential Hypertension

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Khawaja, Muhammad Rizwanulhaq ; Taj, Fawad ; Ahmad, Usman ; Saleheen, Danish ; Jafar, Tazeen ; Frossard, Philippe M. / Association of endothelial nitric oxide synthase gene G894T polymorphism with essential hypertension in an adult Pakistani Pathan population. In: International Journal of Cardiology. 2007 ; Vol. 116, No. 1. pp. 113-115.
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Association of endothelial nitric oxide synthase gene G894T polymorphism with essential hypertension in an adult Pakistani Pathan population. / Khawaja, Muhammad Rizwanulhaq; Taj, Fawad; Ahmad, Usman; Saleheen, Danish; Jafar, Tazeen; Frossard, Philippe M.

In: International Journal of Cardiology, Vol. 116, No. 1, 02.03.2007, p. 113-115.

Research output: Contribution to journalArticle

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