Association of estrogen receptor and glucocorticoid receptor gene polymorphisms with sporadic breast cancer

Joanne E. Curran, Rod A. Lea, Sue Rutherford, Stephen R. Weinstein, Lyn R. Griffiths

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

We have utilized a cross-sectional association approach to investigate sporadic breast cancer. Polymorphisms in 2 candidate genes, ESRα and GRL, were examined in an unrelated breast cancer-affected and age-matched control population. Several polymorphic regions within the ESRα gene have been identified, and some alleles of these polymorphisms have been found to occur at increased levels in breast-cancer patients. Additionally, variations in GRL have the potential to disrupt cell transcription and may be associated with cancer formation. We analyzed 3 polymorphisms, from codons 10 (TCT to TCC), 325 (CCC to CCG) and 594 (ACA to ACG) of ESRα, and a highly polymorphic dinucleotide repeat, D5S207, located within 200 kb of the GRL. When allelc frequencies of the codon 594 (exon 8) ESR polymorphism were compared between affected and unaffected populations, a significant difference was observed (p = 0.005). Results from the D5S207 dinucleotide repeat located near GRL also indicated a significant difference between the tested case and control populations (p = 0.001). Allelic frequencies of the codon 10 and codon 325 ESR polymorphisms were not significantly different between populations (p = 0.152 and 0.181, respectively). Our results indicate that specific alleles of the ESR gene (α subtype) and a marker for the GRL gene locus are associated with sporadic breast-cancer development in the tested Caucasian population and justify further investigation of the role of these and other nuclear steroid receptors in the etiology of breast cancer.

Original languageEnglish (US)
Pages (from-to)271-275
Number of pages5
JournalInternational Journal of Cancer
Volume95
Issue number4
DOIs
StatePublished - Jul 20 2001

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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