Association of IGF axis hormones with waist-to-hip ratio varies by physical activity

Kathryn Schmitz, Dawei Xie, Valerie Teal, Rachel Ballard-Barbash, David Berrigan

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Abstract

Background/Aim: Insulin-like growth factor (IGF) axis hormones are associated with multiple chronic diseases. Reports of the relationship between adiposity and IGF-axis hormones vary widely. This study hypothesized that physical activity levels modify the association of IGF axis hormones with adiposity. Patients and Methods: Data from NHANES III were used to assess whether associations of adiposity, namely waist-to-hip ratio (WHR), with IGF axis hormones varied according to physical activity. Results: Among those in the lowest physical activity quintile, WHR had a substantive inverse association: bioavailable IGF-I was 16% lower among those in the highest versus the lowest WHR quintiles among the least active subjects (p<0.001). By comparison, among those in the highest physical activity quintile, IGF-I did not vary by WHR. Conclusion: The association of bioavailable IGF-1 with central adiposity differs among active versus inactive adults in the USA. This has relevance to understanding previously reported benefits of physical activity among overweight individuals.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalIn Vivo
Volume25
Issue number2
StatePublished - Mar 1 2011

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Schmitz, K., Xie, D., Teal, V., Ballard-Barbash, R., & Berrigan, D. (2011). Association of IGF axis hormones with waist-to-hip ratio varies by physical activity. In Vivo, 25(2), 245-250.