Association of physical activity with reproductive hormones: The penn ovarian aging study

Kathryn Schmitz, Hui Lin, Mary D. Sammel, Clarissa R. Gracia, Deborah B. Nelson, Shiv Kapoor, Tracey L. DeBlasis, Ellen W. Freeman

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Physical activity is associated with reduced risk for breast cancer, perhaps through reductions in circulating reproductive hormones (estrogens and androgens). There may also be a role for physical activity in regulating menopausal symptoms. Few studies have examined associations of physical activity on hormone levels. None have examined the potential effect of the menopausal transition on the associations between physical activity and reproductive hormone levels. Materials and Methods: Data from the Penn Ovarian Aging Study were used for this analysis. Self-reported physical activity was assessed in 391 women up to four times over 10 years and extending across the menopausal transition. Other assessments included reproductive hormones via RIA (estradiol, luteinizing hormone, follicle-stimulating hormone, testosterone, DHEA sulfate), body weight, and height. Multivariate repeated measures regression models were developed to compare reproductive hormone levels within physical activity tertiles, adjusting for age, follow-up time, smoking, and ethnicity. Results: Activity level was inversely associated with estradiol in the subgroup in the late transition stage. Adjusted means for estradiol were 24.6 and 37.9, a relative difference of 54% in estradiol when comparing highest to lowest activity tertile (P = 0.02). Similarly, in this subgroup, there was an inverse association between physical activity and testosterone levels (means of 11.1 and 15.94 in the highest and lowest tertile, a 47% relative difference; P = 0.01). There were no significant associations of activity with any other reproductive hormone. Conclusions: These results identify a particular window of the menopausal transition during which physical activity is associated with reduced estradiol and/or testosterone levels.

Original languageEnglish (US)
Pages (from-to)2042-2047
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2007

Fingerprint

Hormones
Exercise
Estradiol
Testosterone
Dehydroepiandrosterone Sulfate
Body Height
Follicle Stimulating Hormone
Luteinizing Hormone
Androgens
Estrogens
Smoking
Body Weight
Breast Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Schmitz, Kathryn ; Lin, Hui ; Sammel, Mary D. ; Gracia, Clarissa R. ; Nelson, Deborah B. ; Kapoor, Shiv ; DeBlasis, Tracey L. ; Freeman, Ellen W. / Association of physical activity with reproductive hormones : The penn ovarian aging study. In: Cancer Epidemiology Biomarkers and Prevention. 2007 ; Vol. 16, No. 10. pp. 2042-2047.
@article{f0c3a026fe5a4a4c99e84bb39c1ced04,
title = "Association of physical activity with reproductive hormones: The penn ovarian aging study",
abstract = "Background: Physical activity is associated with reduced risk for breast cancer, perhaps through reductions in circulating reproductive hormones (estrogens and androgens). There may also be a role for physical activity in regulating menopausal symptoms. Few studies have examined associations of physical activity on hormone levels. None have examined the potential effect of the menopausal transition on the associations between physical activity and reproductive hormone levels. Materials and Methods: Data from the Penn Ovarian Aging Study were used for this analysis. Self-reported physical activity was assessed in 391 women up to four times over 10 years and extending across the menopausal transition. Other assessments included reproductive hormones via RIA (estradiol, luteinizing hormone, follicle-stimulating hormone, testosterone, DHEA sulfate), body weight, and height. Multivariate repeated measures regression models were developed to compare reproductive hormone levels within physical activity tertiles, adjusting for age, follow-up time, smoking, and ethnicity. Results: Activity level was inversely associated with estradiol in the subgroup in the late transition stage. Adjusted means for estradiol were 24.6 and 37.9, a relative difference of 54{\%} in estradiol when comparing highest to lowest activity tertile (P = 0.02). Similarly, in this subgroup, there was an inverse association between physical activity and testosterone levels (means of 11.1 and 15.94 in the highest and lowest tertile, a 47{\%} relative difference; P = 0.01). There were no significant associations of activity with any other reproductive hormone. Conclusions: These results identify a particular window of the menopausal transition during which physical activity is associated with reduced estradiol and/or testosterone levels.",
author = "Kathryn Schmitz and Hui Lin and Sammel, {Mary D.} and Gracia, {Clarissa R.} and Nelson, {Deborah B.} and Shiv Kapoor and DeBlasis, {Tracey L.} and Freeman, {Ellen W.}",
year = "2007",
month = "10",
day = "1",
doi = "10.1158/1055-9965.EPI-07-0061",
language = "English (US)",
volume = "16",
pages = "2042--2047",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "10",

}

Schmitz, K, Lin, H, Sammel, MD, Gracia, CR, Nelson, DB, Kapoor, S, DeBlasis, TL & Freeman, EW 2007, 'Association of physical activity with reproductive hormones: The penn ovarian aging study', Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 10, pp. 2042-2047. https://doi.org/10.1158/1055-9965.EPI-07-0061

Association of physical activity with reproductive hormones : The penn ovarian aging study. / Schmitz, Kathryn; Lin, Hui; Sammel, Mary D.; Gracia, Clarissa R.; Nelson, Deborah B.; Kapoor, Shiv; DeBlasis, Tracey L.; Freeman, Ellen W.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 16, No. 10, 01.10.2007, p. 2042-2047.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of physical activity with reproductive hormones

T2 - The penn ovarian aging study

AU - Schmitz, Kathryn

AU - Lin, Hui

AU - Sammel, Mary D.

AU - Gracia, Clarissa R.

AU - Nelson, Deborah B.

AU - Kapoor, Shiv

AU - DeBlasis, Tracey L.

AU - Freeman, Ellen W.

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Background: Physical activity is associated with reduced risk for breast cancer, perhaps through reductions in circulating reproductive hormones (estrogens and androgens). There may also be a role for physical activity in regulating menopausal symptoms. Few studies have examined associations of physical activity on hormone levels. None have examined the potential effect of the menopausal transition on the associations between physical activity and reproductive hormone levels. Materials and Methods: Data from the Penn Ovarian Aging Study were used for this analysis. Self-reported physical activity was assessed in 391 women up to four times over 10 years and extending across the menopausal transition. Other assessments included reproductive hormones via RIA (estradiol, luteinizing hormone, follicle-stimulating hormone, testosterone, DHEA sulfate), body weight, and height. Multivariate repeated measures regression models were developed to compare reproductive hormone levels within physical activity tertiles, adjusting for age, follow-up time, smoking, and ethnicity. Results: Activity level was inversely associated with estradiol in the subgroup in the late transition stage. Adjusted means for estradiol were 24.6 and 37.9, a relative difference of 54% in estradiol when comparing highest to lowest activity tertile (P = 0.02). Similarly, in this subgroup, there was an inverse association between physical activity and testosterone levels (means of 11.1 and 15.94 in the highest and lowest tertile, a 47% relative difference; P = 0.01). There were no significant associations of activity with any other reproductive hormone. Conclusions: These results identify a particular window of the menopausal transition during which physical activity is associated with reduced estradiol and/or testosterone levels.

AB - Background: Physical activity is associated with reduced risk for breast cancer, perhaps through reductions in circulating reproductive hormones (estrogens and androgens). There may also be a role for physical activity in regulating menopausal symptoms. Few studies have examined associations of physical activity on hormone levels. None have examined the potential effect of the menopausal transition on the associations between physical activity and reproductive hormone levels. Materials and Methods: Data from the Penn Ovarian Aging Study were used for this analysis. Self-reported physical activity was assessed in 391 women up to four times over 10 years and extending across the menopausal transition. Other assessments included reproductive hormones via RIA (estradiol, luteinizing hormone, follicle-stimulating hormone, testosterone, DHEA sulfate), body weight, and height. Multivariate repeated measures regression models were developed to compare reproductive hormone levels within physical activity tertiles, adjusting for age, follow-up time, smoking, and ethnicity. Results: Activity level was inversely associated with estradiol in the subgroup in the late transition stage. Adjusted means for estradiol were 24.6 and 37.9, a relative difference of 54% in estradiol when comparing highest to lowest activity tertile (P = 0.02). Similarly, in this subgroup, there was an inverse association between physical activity and testosterone levels (means of 11.1 and 15.94 in the highest and lowest tertile, a 47% relative difference; P = 0.01). There were no significant associations of activity with any other reproductive hormone. Conclusions: These results identify a particular window of the menopausal transition during which physical activity is associated with reduced estradiol and/or testosterone levels.

UR - http://www.scopus.com/inward/record.url?scp=35448986903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35448986903&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-07-0061

DO - 10.1158/1055-9965.EPI-07-0061

M3 - Article

C2 - 17905944

AN - SCOPUS:35448986903

VL - 16

SP - 2042

EP - 2047

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 10

ER -