Association of selenium status and blood glutathione concentrations in blacks and whites

John P. Richie, Joshua E. Muscat, Irina Ellison, Ana Calcagnotto, Wayne Kleinman, Karam El-Bayoumy

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Selenium deficiency has been linked with increased cancer risk and, in some studies, selenium supplementation was protective against certain cancers. Previous studies have suggested that selenium chemoprevention may involve reduced oxidative stress through enhanced glutathione (GSH). Our objectives were to examine the relationships between selenium and GSH in the blood and the modifying effects of race and sex in free-living adults and individuals supplemented with selenium. Plasma selenium concentrations and free and bound GSH concentrations and γ-glutamyl cysteine ligase (GCL) activity in the blood were measured in 336 healthy adults (161 Blacks, 175 Whites). Plasma selenium and blood GSH were also measured in 36 healthy men from our previously conducted placebo-controlled trial of selenium-enriched yeast (247 μg/day for 9 mo). In free-living adults, selenium concentrations were associated with increased blood GSH concentration and GCL activity (P < 0.05). Further, selenium was significantly higher in Whites than in Blacks (P < 0.01). After 9 mo of supplementation, plasma selenium increased 114% in Whites and 50% in Blacks (P < 0.05), and blood GSH increased 35% in Whites (P < 0.05) but was unchanged in Blacks. These results indicate a direct association between selenium and GSH in the blood of both free-living and selenium-supplemented individuals, with race being an important modifying factor.

Original languageEnglish (US)
Pages (from-to)367-375
Number of pages9
JournalNutrition and cancer
Volume63
Issue number3
DOIs
StatePublished - Apr 1 2011

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Selenium
Glutathione
Ligases
hydroquinone
Cysteine
Chemoprevention
Neoplasms
Oxidative Stress
Yeasts
Placebos

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

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abstract = "Selenium deficiency has been linked with increased cancer risk and, in some studies, selenium supplementation was protective against certain cancers. Previous studies have suggested that selenium chemoprevention may involve reduced oxidative stress through enhanced glutathione (GSH). Our objectives were to examine the relationships between selenium and GSH in the blood and the modifying effects of race and sex in free-living adults and individuals supplemented with selenium. Plasma selenium concentrations and free and bound GSH concentrations and γ-glutamyl cysteine ligase (GCL) activity in the blood were measured in 336 healthy adults (161 Blacks, 175 Whites). Plasma selenium and blood GSH were also measured in 36 healthy men from our previously conducted placebo-controlled trial of selenium-enriched yeast (247 μg/day for 9 mo). In free-living adults, selenium concentrations were associated with increased blood GSH concentration and GCL activity (P < 0.05). Further, selenium was significantly higher in Whites than in Blacks (P < 0.01). After 9 mo of supplementation, plasma selenium increased 114{\%} in Whites and 50{\%} in Blacks (P < 0.05), and blood GSH increased 35{\%} in Whites (P < 0.05) but was unchanged in Blacks. These results indicate a direct association between selenium and GSH in the blood of both free-living and selenium-supplemented individuals, with race being an important modifying factor.",
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Association of selenium status and blood glutathione concentrations in blacks and whites. / Richie, John P.; Muscat, Joshua E.; Ellison, Irina; Calcagnotto, Ana; Kleinman, Wayne; El-Bayoumy, Karam.

In: Nutrition and cancer, Vol. 63, No. 3, 01.04.2011, p. 367-375.

Research output: Contribution to journalArticle

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