Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence

Moderation × Preventive intervention

Hobart H. Cleveland, III, Gabriel L. Schlomer, David John Vandenbergh, Pedro S.A. Wolf, Mark Ethan Feinberg, Mark T. Greenberg, Richard L. Spoth, Cleve Redmond

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Data from the in-school sample of the PROSPER preventive intervention dissemination trial were used to investigate associations between alcohol dehydrogenase genes and alcohol use across adolescence, and whether substance misuse interventions in the 6th and 7th grades (targeting parenting, family functioning, social norms, youth decision making, and peer group affiliations) modified associations between these genes and adolescent use. Primary analyses were run on a sample of 1,885 individuals and included three steps. First, we estimated unconditional growth curve models with separate slopes for alcohol use from 6th to 9th grade and from 9th to 12th grade, as well as the intercept at Grade 9. Second, we used intervention condition and three alcohol dehydrogenase genes, 1B (ADH1B), 1C (ADH1C), and 4 (ADH4) to predict variance in slopes and intercept. Third, we examined whether genetic influences on model slopes and intercepts were moderated by intervention condition. The results indicated that the increase in alcohol use was greater in early adolescence than in middle adolescence; two of the genes, ADH1B and ADH1C, significantly predicted early adolescent slope and Grade 9 intercept, and associations between ADH1C and both early adolescent slope and intercept were significantly different across control and intervention conditions.

Original languageEnglish (US)
Pages (from-to)297-313
Number of pages17
JournalDevelopment and Psychopathology
Volume30
Issue number1
DOIs
StatePublished - Feb 1 2018

Fingerprint

Alcohol Dehydrogenase
Alcohols
Genes
Peer Group
Parenting
Decision Making
Growth

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

@article{46f728be1ca4418cb70483aaf5ef5e31,
title = "Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention",
abstract = "Data from the in-school sample of the PROSPER preventive intervention dissemination trial were used to investigate associations between alcohol dehydrogenase genes and alcohol use across adolescence, and whether substance misuse interventions in the 6th and 7th grades (targeting parenting, family functioning, social norms, youth decision making, and peer group affiliations) modified associations between these genes and adolescent use. Primary analyses were run on a sample of 1,885 individuals and included three steps. First, we estimated unconditional growth curve models with separate slopes for alcohol use from 6th to 9th grade and from 9th to 12th grade, as well as the intercept at Grade 9. Second, we used intervention condition and three alcohol dehydrogenase genes, 1B (ADH1B), 1C (ADH1C), and 4 (ADH4) to predict variance in slopes and intercept. Third, we examined whether genetic influences on model slopes and intercepts were moderated by intervention condition. The results indicated that the increase in alcohol use was greater in early adolescence than in middle adolescence; two of the genes, ADH1B and ADH1C, significantly predicted early adolescent slope and Grade 9 intercept, and associations between ADH1C and both early adolescent slope and intercept were significantly different across control and intervention conditions.",
author = "{Cleveland, III}, {Hobart H.} and Schlomer, {Gabriel L.} and Vandenbergh, {David John} and Wolf, {Pedro S.A.} and Feinberg, {Mark Ethan} and Greenberg, {Mark T.} and Spoth, {Richard L.} and Cleve Redmond",
year = "2018",
month = "2",
day = "1",
doi = "10.1017/S0954579417000633",
language = "English (US)",
volume = "30",
pages = "297--313",
journal = "Development and Psychopathology",
issn = "0954-5794",
publisher = "Cambridge University Press",
number = "1",

}

Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence : Moderation × Preventive intervention. / Cleveland, III, Hobart H.; Schlomer, Gabriel L.; Vandenbergh, David John; Wolf, Pedro S.A.; Feinberg, Mark Ethan; Greenberg, Mark T.; Spoth, Richard L.; Redmond, Cleve.

In: Development and Psychopathology, Vol. 30, No. 1, 01.02.2018, p. 297-313.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence

T2 - Moderation × Preventive intervention

AU - Cleveland, III, Hobart H.

AU - Schlomer, Gabriel L.

AU - Vandenbergh, David John

AU - Wolf, Pedro S.A.

AU - Feinberg, Mark Ethan

AU - Greenberg, Mark T.

AU - Spoth, Richard L.

AU - Redmond, Cleve

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Data from the in-school sample of the PROSPER preventive intervention dissemination trial were used to investigate associations between alcohol dehydrogenase genes and alcohol use across adolescence, and whether substance misuse interventions in the 6th and 7th grades (targeting parenting, family functioning, social norms, youth decision making, and peer group affiliations) modified associations between these genes and adolescent use. Primary analyses were run on a sample of 1,885 individuals and included three steps. First, we estimated unconditional growth curve models with separate slopes for alcohol use from 6th to 9th grade and from 9th to 12th grade, as well as the intercept at Grade 9. Second, we used intervention condition and three alcohol dehydrogenase genes, 1B (ADH1B), 1C (ADH1C), and 4 (ADH4) to predict variance in slopes and intercept. Third, we examined whether genetic influences on model slopes and intercepts were moderated by intervention condition. The results indicated that the increase in alcohol use was greater in early adolescence than in middle adolescence; two of the genes, ADH1B and ADH1C, significantly predicted early adolescent slope and Grade 9 intercept, and associations between ADH1C and both early adolescent slope and intercept were significantly different across control and intervention conditions.

AB - Data from the in-school sample of the PROSPER preventive intervention dissemination trial were used to investigate associations between alcohol dehydrogenase genes and alcohol use across adolescence, and whether substance misuse interventions in the 6th and 7th grades (targeting parenting, family functioning, social norms, youth decision making, and peer group affiliations) modified associations between these genes and adolescent use. Primary analyses were run on a sample of 1,885 individuals and included three steps. First, we estimated unconditional growth curve models with separate slopes for alcohol use from 6th to 9th grade and from 9th to 12th grade, as well as the intercept at Grade 9. Second, we used intervention condition and three alcohol dehydrogenase genes, 1B (ADH1B), 1C (ADH1C), and 4 (ADH4) to predict variance in slopes and intercept. Third, we examined whether genetic influences on model slopes and intercepts were moderated by intervention condition. The results indicated that the increase in alcohol use was greater in early adolescence than in middle adolescence; two of the genes, ADH1B and ADH1C, significantly predicted early adolescent slope and Grade 9 intercept, and associations between ADH1C and both early adolescent slope and intercept were significantly different across control and intervention conditions.

UR - http://www.scopus.com/inward/record.url?scp=85019607169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019607169&partnerID=8YFLogxK

U2 - 10.1017/S0954579417000633

DO - 10.1017/S0954579417000633

M3 - Article

VL - 30

SP - 297

EP - 313

JO - Development and Psychopathology

JF - Development and Psychopathology

SN - 0954-5794

IS - 1

ER -