Associations Between Fetal Growth and Self-Perceived Health Throughout Adulthood: A Co-twin Control Study

Miriam A. Mosing, Sven Cnattingius, Margaret Gatz, Jenae Marie Neiderhiser, Nancy L. Pedersen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The literature shows evidence for long-lasting effects of low birth weight (LBW) on many health outcomes, but little is known about effects on self-perceived health. Findings are mixed and studies are small, mostly focusing on LBW effects on health outcomes before adulthood. Further, as LBW and most health conditions including self-perceived health are partly heritable, associations between birth weight (BW) and adverse health outcomes may also be due to shared genetic as well as other (pre- and postnatal) unmeasured environmental influences. We explored LBW effects on self-perceived health in early and later adulthood using a very large and genetically informative sample of more than 50,000 Swedish twins. In addition, analyses within twin pairs (the co-twin control design) were used to examine potential associations between BW and the offspring’s risk for poor self-perceived health independent of shared environmental or genetic factors, evidence which is critical for the understanding of underlying mechanisms. Results showed that lower BW was significantly associated with poorer self-perceived health during adulthood, although the effect size was small. Co-twin control analyses suggested that this increased risk may be due to shared underlying liability (environmental or genetic) rather than a direct effect of BW, but findings were not conclusive.

Original languageEnglish (US)
Pages (from-to)457-466
Number of pages10
JournalBehavior Genetics
Volume46
Issue number3
DOIs
StatePublished - May 1 2016

Fingerprint

Twin Studies
low birth weight
fetal development
Fetal Development
adulthood
birth weight
Health
Low Birth Weight Infant
Birth Weight
health
effect
sampling

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

Cite this

Mosing, Miriam A. ; Cnattingius, Sven ; Gatz, Margaret ; Neiderhiser, Jenae Marie ; Pedersen, Nancy L. / Associations Between Fetal Growth and Self-Perceived Health Throughout Adulthood : A Co-twin Control Study. In: Behavior Genetics. 2016 ; Vol. 46, No. 3. pp. 457-466.
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Associations Between Fetal Growth and Self-Perceived Health Throughout Adulthood : A Co-twin Control Study. / Mosing, Miriam A.; Cnattingius, Sven; Gatz, Margaret; Neiderhiser, Jenae Marie; Pedersen, Nancy L.

In: Behavior Genetics, Vol. 46, No. 3, 01.05.2016, p. 457-466.

Research output: Contribution to journalArticle

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