Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis

Nancy Olsen, Leigh F. Callahan, Raye H. Brooks, Paul Nance, Jeremy J. Kaye, Peter Stastny, Theodore Pincus

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalThe American journal of medicine
Volume84
Issue number2
DOIs
StatePublished - Jan 1 1988

Fingerprint

HLA-DR4 Antigen
Rheumatoid Factor
Rheumatoid Arthritis
HLA-DR1 Antigen
Joints
Demography

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Olsen, Nancy ; Callahan, Leigh F. ; Brooks, Raye H. ; Nance, Paul ; Kaye, Jeremy J. ; Stastny, Peter ; Pincus, Theodore. / Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis. In: The American journal of medicine. 1988 ; Vol. 84, No. 2. pp. 257-264.
@article{41e0d5a56b5049baa772d917515e72ee,
title = "Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis",
abstract = "Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.",
author = "Nancy Olsen and Callahan, {Leigh F.} and Brooks, {Raye H.} and Paul Nance and Kaye, {Jeremy J.} and Peter Stastny and Theodore Pincus",
year = "1988",
month = "1",
day = "1",
doi = "10.1016/0002-9343(88)90422-6",
language = "English (US)",
volume = "84",
pages = "257--264",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "2",

}

Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis. / Olsen, Nancy; Callahan, Leigh F.; Brooks, Raye H.; Nance, Paul; Kaye, Jeremy J.; Stastny, Peter; Pincus, Theodore.

In: The American journal of medicine, Vol. 84, No. 2, 01.01.1988, p. 257-264.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis

AU - Olsen, Nancy

AU - Callahan, Leigh F.

AU - Brooks, Raye H.

AU - Nance, Paul

AU - Kaye, Jeremy J.

AU - Stastny, Peter

AU - Pincus, Theodore

PY - 1988/1/1

Y1 - 1988/1/1

N2 - Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.

AB - Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4.

UR - http://www.scopus.com/inward/record.url?scp=0023868510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023868510&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(88)90422-6

DO - 10.1016/0002-9343(88)90422-6

M3 - Article

C2 - 3261537

AN - SCOPUS:0023868510

VL - 84

SP - 257

EP - 264

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 2

ER -