Asymmetric dimethylarginine in adults with cystathionine β-synthase deficiency

Monica S. Rocha, Tom Teerlink, Mirian C.H. Janssen, Leo A.J. Kluijtmans, Yvo Smulders, Cornelis Jakobs, Isabel Tavares de Almeida, Isabel Rivera, Maria Rita Castro, Henk J. Blom

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

In hyperhomocysteinemia (HHcy), an independent risk factor for cardiovascular diseases, endothelial dysfunction due to reduced bioavailability of nitric oxide is a consistent finding. However, the underlying mechanisms remain unknown.Increased levels of the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) have been associated with HHcy, and may contribute, at least in part, for the homocysteine-induced endothelial dysfunction, but whether cystathionine β-synthase (CBS) deficiency is associated with increased ADMA has hardly been investigated.To address this question, we measured total homocysteine (tHcy), ADMA and symmetric dimethylarginine (SDMA) in plasma of 22 adult CBS deficient patients, using established HPLC techniques. Results showed that in CBS deficient patients with elevated levels of tHcy (median (total range): 33 (14-237)μmol/L), both ADMA and SDMA levels were normal. Moreover, tHcy and ADMA concentrations were not correlated (rs=0.017, p=0.94). Our results favor the hypothesis that the negative vascular effects of HHcy have an ADMA-independent etiology.

Original languageEnglish (US)
Pages (from-to)509-511
Number of pages3
JournalAtherosclerosis
Volume222
Issue number2
DOIs
StatePublished - Jun 1 2012

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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