Asymmetrical lateral ventricular enlargement in Parkinson's disease

M. M. Lewis, A. B. Smith, M. Styner, H. Gu, R. Poole, H. Zhu, Y. Li, X. Barbero, S. Gouttard, M. J. McKeown, R. B. Mailman, X. Huang

Research output: Contribution to journalArticle

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Abstract

Background: A recent case report suggested the presence of asymmetrical lateral ventricular enlargement associated with motor asymmetry in Parkinson's disease (PD). The current study explored these associations further. Methods: Magnetic resonance imaging (3T) scans were obtained on 17 PD and 15 healthy control subjects at baseline and 12-43 months later. Baseline and longitudinal lateral ventricular volumetric changes were compared between contralateral and ipsilateral ventricles in PD subjects relative to symptom onset side and in controls relative to their dominant hand. Correlations between changes in ventricular volume and United Parkinson's disease rating scale motor scores (UPDRS-III) whilst on medication were determined. Results: The lateral ventricle contralateral to symptom onset side displayed a faster rate of enlargement compared to the ipsilateral (P = 0.004) in PD subjects, with no such asymmetry detected (P = 0.312) in controls. There was a positive correlation between ventricular enlargement and worsening motor function assessed by UPDRS-III scores (r = 0.96, P < 0.001). Discussion: There is asymmetrical lateral ventricular enlargement that is associated with PD motor asymmetry and progression. Further studies are warranted to investigate the underlying mechanism(s), as well as the potential of using volumetric measurements as a marker for PD progression.

Original languageEnglish (US)
Pages (from-to)475-481
Number of pages7
JournalEuropean Journal of Neurology
Volume16
Issue number4
DOIs
StatePublished - Apr 1 2009

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Parkinson Disease
Lateral Ventricles
Disease Progression
Healthy Volunteers
Hand
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Lewis, M. M. ; Smith, A. B. ; Styner, M. ; Gu, H. ; Poole, R. ; Zhu, H. ; Li, Y. ; Barbero, X. ; Gouttard, S. ; McKeown, M. J. ; Mailman, R. B. ; Huang, X. / Asymmetrical lateral ventricular enlargement in Parkinson's disease. In: European Journal of Neurology. 2009 ; Vol. 16, No. 4. pp. 475-481.
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Lewis, MM, Smith, AB, Styner, M, Gu, H, Poole, R, Zhu, H, Li, Y, Barbero, X, Gouttard, S, McKeown, MJ, Mailman, RB & Huang, X 2009, 'Asymmetrical lateral ventricular enlargement in Parkinson's disease', European Journal of Neurology, vol. 16, no. 4, pp. 475-481. https://doi.org/10.1111/j.1468-1331.2008.02430.x

Asymmetrical lateral ventricular enlargement in Parkinson's disease. / Lewis, M. M.; Smith, A. B.; Styner, M.; Gu, H.; Poole, R.; Zhu, H.; Li, Y.; Barbero, X.; Gouttard, S.; McKeown, M. J.; Mailman, R. B.; Huang, X.

In: European Journal of Neurology, Vol. 16, No. 4, 01.04.2009, p. 475-481.

Research output: Contribution to journalArticle

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AU - Styner, M.

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AU - Zhu, H.

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N2 - Background: A recent case report suggested the presence of asymmetrical lateral ventricular enlargement associated with motor asymmetry in Parkinson's disease (PD). The current study explored these associations further. Methods: Magnetic resonance imaging (3T) scans were obtained on 17 PD and 15 healthy control subjects at baseline and 12-43 months later. Baseline and longitudinal lateral ventricular volumetric changes were compared between contralateral and ipsilateral ventricles in PD subjects relative to symptom onset side and in controls relative to their dominant hand. Correlations between changes in ventricular volume and United Parkinson's disease rating scale motor scores (UPDRS-III) whilst on medication were determined. Results: The lateral ventricle contralateral to symptom onset side displayed a faster rate of enlargement compared to the ipsilateral (P = 0.004) in PD subjects, with no such asymmetry detected (P = 0.312) in controls. There was a positive correlation between ventricular enlargement and worsening motor function assessed by UPDRS-III scores (r = 0.96, P < 0.001). Discussion: There is asymmetrical lateral ventricular enlargement that is associated with PD motor asymmetry and progression. Further studies are warranted to investigate the underlying mechanism(s), as well as the potential of using volumetric measurements as a marker for PD progression.

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