Abstract

Although icosahedral viruses have obvious and highly symmetrical features, asymmetric structural elements are also present. Asymmetric features may be inherent since the genome and location of minor capsid proteins are typically incorporated without adhering to icosahedral symmetry. Asymmetry also develops during the virus life cycle in order to accomplish key functions such as genome packaging, release, and organization. However, resolving asymmetric features complicates image processing during single-particle cryoEM analysis. This review summarizes the current state of knowledge regarding asymmetric structural features with specific examples drawn from members of picornaviridae, parvoviradae, microviradae, and leviviridae.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalCurrent Opinion in Virology
Volume36
DOIs
StatePublished - Jun 1 2019

Fingerprint

Leviviridae
Genome
Viruses
Picornaviridae
Capsid Proteins
Product Packaging
Life Cycle Stages

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

Goetschius, Daniel J. ; Parrish, Colin R. ; Hafenstein, Susan. / Asymmetry in icosahedral viruses. In: Current Opinion in Virology. 2019 ; Vol. 36. pp. 67-73.
@article{b30d90f1688d4b93ad6d551b16bdbae4,
title = "Asymmetry in icosahedral viruses",
abstract = "Although icosahedral viruses have obvious and highly symmetrical features, asymmetric structural elements are also present. Asymmetric features may be inherent since the genome and location of minor capsid proteins are typically incorporated without adhering to icosahedral symmetry. Asymmetry also develops during the virus life cycle in order to accomplish key functions such as genome packaging, release, and organization. However, resolving asymmetric features complicates image processing during single-particle cryoEM analysis. This review summarizes the current state of knowledge regarding asymmetric structural features with specific examples drawn from members of picornaviridae, parvoviradae, microviradae, and leviviridae.",
author = "Goetschius, {Daniel J.} and Parrish, {Colin R.} and Susan Hafenstein",
year = "2019",
month = "6",
day = "1",
doi = "10.1016/j.coviro.2019.05.006",
language = "English (US)",
volume = "36",
pages = "67--73",
journal = "Current Opinion in Virology",
issn = "1879-6257",
publisher = "Elsevier BV",

}

Asymmetry in icosahedral viruses. / Goetschius, Daniel J.; Parrish, Colin R.; Hafenstein, Susan.

In: Current Opinion in Virology, Vol. 36, 01.06.2019, p. 67-73.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Asymmetry in icosahedral viruses

AU - Goetschius, Daniel J.

AU - Parrish, Colin R.

AU - Hafenstein, Susan

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Although icosahedral viruses have obvious and highly symmetrical features, asymmetric structural elements are also present. Asymmetric features may be inherent since the genome and location of minor capsid proteins are typically incorporated without adhering to icosahedral symmetry. Asymmetry also develops during the virus life cycle in order to accomplish key functions such as genome packaging, release, and organization. However, resolving asymmetric features complicates image processing during single-particle cryoEM analysis. This review summarizes the current state of knowledge regarding asymmetric structural features with specific examples drawn from members of picornaviridae, parvoviradae, microviradae, and leviviridae.

AB - Although icosahedral viruses have obvious and highly symmetrical features, asymmetric structural elements are also present. Asymmetric features may be inherent since the genome and location of minor capsid proteins are typically incorporated without adhering to icosahedral symmetry. Asymmetry also develops during the virus life cycle in order to accomplish key functions such as genome packaging, release, and organization. However, resolving asymmetric features complicates image processing during single-particle cryoEM analysis. This review summarizes the current state of knowledge regarding asymmetric structural features with specific examples drawn from members of picornaviridae, parvoviradae, microviradae, and leviviridae.

UR - http://www.scopus.com/inward/record.url?scp=85067784440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067784440&partnerID=8YFLogxK

U2 - 10.1016/j.coviro.2019.05.006

DO - 10.1016/j.coviro.2019.05.006

M3 - Review article

C2 - 31255982

AN - SCOPUS:85067784440

VL - 36

SP - 67

EP - 73

JO - Current Opinion in Virology

JF - Current Opinion in Virology

SN - 1879-6257

ER -