Asymmetry in the Cortical and Trabecular Bone of the Human Humerus During Development

Bernadette Perchalski, Arielle Placke, Simone M. Sukhdeo, Colin N. Shaw, James H. Gosman, David A. Raichlen, Timothy M. Ryan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Many studies have noted that the bones of the human upper limb display bilateral asymmetry, commonly linking this asymmetry in external and internal morphology to handedness and lateralization. Few studies, however, have attempted to track asymmetry throughout ontogeny. This study assesses the ontogenetic development of cortical and trabecular bone asymmetry in the humerus. We predict that directional asymmetry in structural properties will emerge in concert with hand preference and increased activity levels during the juvenile period. Paired humeri from 57 individuals from the Norris Farms #36 archaeological skeletal collection ranging in age from neonate to adult were used in the current study. Cortical bone cross-sectional properties and three-dimensional trabecular bone structure were quantified from microcomputed tomography data. The results indicate significant absolute asymmetry in all measured cortical and trabecular bone variables across all ages. Trabecular bone displays significantly higher absolute asymmetry than cortical bone. Contrary to expectations, however, this study found very little evidence for significant directional asymmetry in humeral length and cortical or trabecular bone variables, except in adults. The presence of significant absolute asymmetry in all age groups, and the lack of significant directional asymmetry in almost all variables at all ages, suggests that structural differences due to higher levels of habitual loading in the dominant arm are overlain on a template of potentially significant existing asymmetry. Anat Rec, 301:1012–1025, 2018.

Original languageEnglish (US)
Pages (from-to)1012-1025
Number of pages14
JournalAnatomical Record
Volume301
Issue number6
DOIs
StatePublished - Jun 2018

Fingerprint

humerus
Humerus
bone
asymmetry
bones
X-Ray Microtomography
Functional Laterality
Upper Extremity
micro-computed tomography
Arm
Hand
Age Groups
Cancellous Bone
Cortical Bone
Newborn Infant
Bone and Bones
handedness
limbs (animal)
ontogeny
neonate

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Biotechnology
  • Histology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Perchalski, B., Placke, A., Sukhdeo, S. M., Shaw, C. N., Gosman, J. H., Raichlen, D. A., & Ryan, T. M. (2018). Asymmetry in the Cortical and Trabecular Bone of the Human Humerus During Development. Anatomical Record, 301(6), 1012-1025. https://doi.org/10.1002/ar.23705
Perchalski, Bernadette ; Placke, Arielle ; Sukhdeo, Simone M. ; Shaw, Colin N. ; Gosman, James H. ; Raichlen, David A. ; Ryan, Timothy M. / Asymmetry in the Cortical and Trabecular Bone of the Human Humerus During Development. In: Anatomical Record. 2018 ; Vol. 301, No. 6. pp. 1012-1025.
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Perchalski, B, Placke, A, Sukhdeo, SM, Shaw, CN, Gosman, JH, Raichlen, DA & Ryan, TM 2018, 'Asymmetry in the Cortical and Trabecular Bone of the Human Humerus During Development', Anatomical Record, vol. 301, no. 6, pp. 1012-1025. https://doi.org/10.1002/ar.23705

Asymmetry in the Cortical and Trabecular Bone of the Human Humerus During Development. / Perchalski, Bernadette; Placke, Arielle; Sukhdeo, Simone M.; Shaw, Colin N.; Gosman, James H.; Raichlen, David A.; Ryan, Timothy M.

In: Anatomical Record, Vol. 301, No. 6, 06.2018, p. 1012-1025.

Research output: Contribution to journalArticle

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Perchalski B, Placke A, Sukhdeo SM, Shaw CN, Gosman JH, Raichlen DA et al. Asymmetry in the Cortical and Trabecular Bone of the Human Humerus During Development. Anatomical Record. 2018 Jun;301(6):1012-1025. https://doi.org/10.1002/ar.23705