Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar

Myo Thiha Zaw, Myo Thant, Tin Maung Hlaing, Naing Zin Aung, Min Thu, Kanit Phumchuea, Kanokwan Phusri, Teerawat Saeseu, Ritthideach Yorsaeng, Wang Nguitragool, Ingrid Felger, Jaranit Kaewkungwal, Liwang Cui, Jetsumon Sattabongkot

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Myanmar has the heaviest burden of malaria in the Greater Mekong Sub-region. Asymptomatic Plasmodium spp. infections are common in this region and may represent an important reservoir of transmission that must be targeted for malaria elimination. Methods: A mass blood survey was conducted among 485 individuals from six villages in Kayah State, an area of endemic but low transmission malaria in eastern Myanmar. Malaria infection was screened by rapid diagnostic test (RDT), light microscopy and real-time polymerase chain reaction (PCR), and its association with demographic factors was explored. Results: The prevalence of asymptomatic Plasmodium spp. infection was 2.3% (11/485) by real-time PCR. Plasmodium vivax accounted for 72.7% (8/11) and Plasmodium falciparum for 27.3% (3/11) of infections. Men were at greater risk of infection by Plasmodium spp. than women. Individuals who worked as farmers or wood and bamboo cutters had an increased risk of infection. Conclusion: A combination of RDT, light microscopy and PCR diagnostics were used to identify asymptomatic malaria infection, providing additional information on asymptomatic cases in addition to the routine statistics on symptomatic cases, so as to determine the true burden of disease in the area. Such information and risk factors can improve malaria risk stratification and guide decision-makers towards better design and delivery of targeted interventions in small villages, representative of Kayah State.

Original languageEnglish (US)
Article number138
JournalMalaria journal
Volume16
Issue number1
DOIs
StatePublished - Apr 4 2017

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Myanmar
Malaria
Infection
Plasmodium
Routine Diagnostic Tests
Real-Time Polymerase Chain Reaction
Microscopy
Plasmodium vivax
Light
Asymptomatic Infections
Plasmodium falciparum
Demography
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

Cite this

Zaw, M. T., Thant, M., Hlaing, T. M., Aung, N. Z., Thu, M., Phumchuea, K., ... Sattabongkot, J. (2017). Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar. Malaria journal, 16(1), [138]. https://doi.org/10.1186/s12936-017-1789-9
Zaw, Myo Thiha ; Thant, Myo ; Hlaing, Tin Maung ; Aung, Naing Zin ; Thu, Min ; Phumchuea, Kanit ; Phusri, Kanokwan ; Saeseu, Teerawat ; Yorsaeng, Ritthideach ; Nguitragool, Wang ; Felger, Ingrid ; Kaewkungwal, Jaranit ; Cui, Liwang ; Sattabongkot, Jetsumon. / Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar. In: Malaria journal. 2017 ; Vol. 16, No. 1.
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abstract = "Background: Myanmar has the heaviest burden of malaria in the Greater Mekong Sub-region. Asymptomatic Plasmodium spp. infections are common in this region and may represent an important reservoir of transmission that must be targeted for malaria elimination. Methods: A mass blood survey was conducted among 485 individuals from six villages in Kayah State, an area of endemic but low transmission malaria in eastern Myanmar. Malaria infection was screened by rapid diagnostic test (RDT), light microscopy and real-time polymerase chain reaction (PCR), and its association with demographic factors was explored. Results: The prevalence of asymptomatic Plasmodium spp. infection was 2.3{\%} (11/485) by real-time PCR. Plasmodium vivax accounted for 72.7{\%} (8/11) and Plasmodium falciparum for 27.3{\%} (3/11) of infections. Men were at greater risk of infection by Plasmodium spp. than women. Individuals who worked as farmers or wood and bamboo cutters had an increased risk of infection. Conclusion: A combination of RDT, light microscopy and PCR diagnostics were used to identify asymptomatic malaria infection, providing additional information on asymptomatic cases in addition to the routine statistics on symptomatic cases, so as to determine the true burden of disease in the area. Such information and risk factors can improve malaria risk stratification and guide decision-makers towards better design and delivery of targeted interventions in small villages, representative of Kayah State.",
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Zaw, MT, Thant, M, Hlaing, TM, Aung, NZ, Thu, M, Phumchuea, K, Phusri, K, Saeseu, T, Yorsaeng, R, Nguitragool, W, Felger, I, Kaewkungwal, J, Cui, L & Sattabongkot, J 2017, 'Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar', Malaria journal, vol. 16, no. 1, 138. https://doi.org/10.1186/s12936-017-1789-9

Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar. / Zaw, Myo Thiha; Thant, Myo; Hlaing, Tin Maung; Aung, Naing Zin; Thu, Min; Phumchuea, Kanit; Phusri, Kanokwan; Saeseu, Teerawat; Yorsaeng, Ritthideach; Nguitragool, Wang; Felger, Ingrid; Kaewkungwal, Jaranit; Cui, Liwang; Sattabongkot, Jetsumon.

In: Malaria journal, Vol. 16, No. 1, 138, 04.04.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar

AU - Zaw, Myo Thiha

AU - Thant, Myo

AU - Hlaing, Tin Maung

AU - Aung, Naing Zin

AU - Thu, Min

AU - Phumchuea, Kanit

AU - Phusri, Kanokwan

AU - Saeseu, Teerawat

AU - Yorsaeng, Ritthideach

AU - Nguitragool, Wang

AU - Felger, Ingrid

AU - Kaewkungwal, Jaranit

AU - Cui, Liwang

AU - Sattabongkot, Jetsumon

PY - 2017/4/4

Y1 - 2017/4/4

N2 - Background: Myanmar has the heaviest burden of malaria in the Greater Mekong Sub-region. Asymptomatic Plasmodium spp. infections are common in this region and may represent an important reservoir of transmission that must be targeted for malaria elimination. Methods: A mass blood survey was conducted among 485 individuals from six villages in Kayah State, an area of endemic but low transmission malaria in eastern Myanmar. Malaria infection was screened by rapid diagnostic test (RDT), light microscopy and real-time polymerase chain reaction (PCR), and its association with demographic factors was explored. Results: The prevalence of asymptomatic Plasmodium spp. infection was 2.3% (11/485) by real-time PCR. Plasmodium vivax accounted for 72.7% (8/11) and Plasmodium falciparum for 27.3% (3/11) of infections. Men were at greater risk of infection by Plasmodium spp. than women. Individuals who worked as farmers or wood and bamboo cutters had an increased risk of infection. Conclusion: A combination of RDT, light microscopy and PCR diagnostics were used to identify asymptomatic malaria infection, providing additional information on asymptomatic cases in addition to the routine statistics on symptomatic cases, so as to determine the true burden of disease in the area. Such information and risk factors can improve malaria risk stratification and guide decision-makers towards better design and delivery of targeted interventions in small villages, representative of Kayah State.

AB - Background: Myanmar has the heaviest burden of malaria in the Greater Mekong Sub-region. Asymptomatic Plasmodium spp. infections are common in this region and may represent an important reservoir of transmission that must be targeted for malaria elimination. Methods: A mass blood survey was conducted among 485 individuals from six villages in Kayah State, an area of endemic but low transmission malaria in eastern Myanmar. Malaria infection was screened by rapid diagnostic test (RDT), light microscopy and real-time polymerase chain reaction (PCR), and its association with demographic factors was explored. Results: The prevalence of asymptomatic Plasmodium spp. infection was 2.3% (11/485) by real-time PCR. Plasmodium vivax accounted for 72.7% (8/11) and Plasmodium falciparum for 27.3% (3/11) of infections. Men were at greater risk of infection by Plasmodium spp. than women. Individuals who worked as farmers or wood and bamboo cutters had an increased risk of infection. Conclusion: A combination of RDT, light microscopy and PCR diagnostics were used to identify asymptomatic malaria infection, providing additional information on asymptomatic cases in addition to the routine statistics on symptomatic cases, so as to determine the true burden of disease in the area. Such information and risk factors can improve malaria risk stratification and guide decision-makers towards better design and delivery of targeted interventions in small villages, representative of Kayah State.

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