Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer

Erika S. Dahl, Katherine M. Aird

Research output: Contribution to journalShort surveypeer-review

11 Scopus citations

Abstract

The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number of recent studies report a non-canonical role for ATM in the regulation of carbon metabolism. This review highlights what is currently known about ATM's regulation of carbon metabolism, the implication of these pathways in cancer, and the development of ATM inhibitors as therapeutic strategies for cancer.

Original languageEnglish (US)
Article number291
JournalFrontiers in Oncology
Volume7
Issue numberNOV
DOIs
StatePublished - Nov 29 2017

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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