Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer

Erika S. Dahl, Katherine Aird

Research output: Contribution to journalShort survey

5 Citations (Scopus)

Abstract

The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number of recent studies report a non-canonical role for ATM in the regulation of carbon metabolism. This review highlights what is currently known about ATM's regulation of carbon metabolism, the implication of these pathways in cancer, and the development of ATM inhibitors as therapeutic strategies for cancer.

Original languageEnglish (US)
Article number291
JournalFrontiers in Oncology
Volume7
Issue numberNOV
DOIs
StatePublished - Nov 29 2017

Fingerprint

Ataxia Telangiectasia
Carbon
Neoplasms
Ataxia Telangiectasia Mutated Proteins
Biomass
Protein Kinases
DNA Damage
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer. / Dahl, Erika S.; Aird, Katherine.

In: Frontiers in Oncology, Vol. 7, No. NOV, 291, 29.11.2017.

Research output: Contribution to journalShort survey

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T1 - Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer

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AU - Aird, Katherine

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AB - The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number of recent studies report a non-canonical role for ATM in the regulation of carbon metabolism. This review highlights what is currently known about ATM's regulation of carbon metabolism, the implication of these pathways in cancer, and the development of ATM inhibitors as therapeutic strategies for cancer.

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