ATG2 regulation of phagophore expansion at mitochondria-associated ER membranes

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Abstract

The mechanism by which ATG2 (ATG2A and ATG2B in mammals) regulates autophagosome biogenesis remains largely unknown. In our recent study, we showed that ATG2A translocates to the mitochondria-associated ER membranes (MAM) to promote phagophore growth during nutrient starvation. Mechanistically, the mitochondrial translocase TOMM40 binds to a C-terminal domain of ATG2A, termed the MAM localization domain (MLD), and mediates its MAM translocation in a manner dependent on the TOMM receptor TOMM70. Moreover, ATG2A associates with ATG9A through its N-terminal domain and this interaction is required for phagophore expansion and efficient autophagic flux. These observations suggest that ATG2 operates a mechanism for phagophore expansion at the MAM through the TOMM40-TOMM70 complex and ATG9 during autophagy.

Original languageEnglish (US)
Pages (from-to)2165-2166
Number of pages2
JournalAutophagy
Volume15
Issue number12
DOIs
StatePublished - Dec 2 2019

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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