TY - JOUR
T1 - Atomoxetine enhances a short-term model of plasticity in humans
AU - Foster, Donald J.
AU - Good, David C.
AU - Fowlkes, Allison
AU - Sawaki, Lumy
N1 - Funding Information:
Supported by Wake Forest University (intramural grant no. BG 03-644). Drugs used in this study were provided by the Wake Forest University Baptist Medical Center pharmacy.
PY - 2006/2
Y1 - 2006/2
N2 - Objective: To evaluate the role of 2 noradrenergic drugs in modulating use-dependent plasticity in humans. Design: Double-blind, randomized, and placebo-controlled crossover design. Setting: A laboratory in a hospital. Participants: A convenience sample of 10 healthy subjects. Intervention: An established paradigm that measures motor memory as a short-term model of use-dependent plasticity. Subjects attended 3 sessions, separated by at least 1 week to allow drug washout. Subjects received atomoxetine (Strattera), venlafaxine (Effexor), or placebo. Main Outcome Measure: Increase in the proportion of movements into the training target zone (TTZ), an indicator of enhanced plasticity. Results: Atomoxetine, but not venlafaxine, significantly increased movements into the TTZ. Conclusions: These results support a role for norepinephrine in enhancing cortical plasticity and suggest potential benefits in using these drugs for improving motor recovery after stroke.
AB - Objective: To evaluate the role of 2 noradrenergic drugs in modulating use-dependent plasticity in humans. Design: Double-blind, randomized, and placebo-controlled crossover design. Setting: A laboratory in a hospital. Participants: A convenience sample of 10 healthy subjects. Intervention: An established paradigm that measures motor memory as a short-term model of use-dependent plasticity. Subjects attended 3 sessions, separated by at least 1 week to allow drug washout. Subjects received atomoxetine (Strattera), venlafaxine (Effexor), or placebo. Main Outcome Measure: Increase in the proportion of movements into the training target zone (TTZ), an indicator of enhanced plasticity. Results: Atomoxetine, but not venlafaxine, significantly increased movements into the TTZ. Conclusions: These results support a role for norepinephrine in enhancing cortical plasticity and suggest potential benefits in using these drugs for improving motor recovery after stroke.
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U2 - 10.1016/j.apmr.2005.08.131
DO - 10.1016/j.apmr.2005.08.131
M3 - Article
C2 - 16442975
AN - SCOPUS:31444436484
SN - 0003-9993
VL - 87
SP - 216
EP - 221
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
IS - 2
ER -