Atomoxetine, Parent Training, and Their Effects on Sleep in Youth with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder

Jill A. Hollway, Marissa Imee Mendoza-Burcham, Rebecca Andridge, Michael G. Aman, Benjamin Handen, L. Eugene Arnold, Luc Lecavalier, Craig Williams, Laura Silverman, Tristram Smith

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Sleep disturbance is often a problem for children with either autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD). Psychostimulant medications used to treat ADHD symptoms can exacerbate this problem. For children with ASD and ADHD, atomoxetine (ATX) is a viable alternative to psychostimulants. We investigated the effects of ATX and a manualized parent training (PT) program targeting noncompliance, on the sleep quality of children with ASD and ADHD. Methods: Participants in a randomized clinical trial were treated with ATX + PT, ATX alone, PT alone, or placebo (PBO) alone, for 10 weeks. Fifty-four of 128 (42%) caregivers completed the Children's Sleep Habits Questionnaire (CSHQ) at baseline and endpoint. Analysis of covariance was used to investigate possible differences between treatment groups. Results: There were no significant differences between treatment groups, including PBO on the CSHQ 33-Item total score, total hours of sleep per day, and total minutes awake after sleep onset at the study endpoint. Conclusion: ATX appears sleep neutral. Clinicians who treat ADHD symptoms in children and adolescents with ASD may prefer ATX over psychostimulants when sleep disturbance is an issue.

Original languageEnglish (US)
Pages (from-to)130-135
Number of pages6
JournalJournal of Child and Adolescent Psychopharmacology
Volume28
Issue number2
DOIs
StatePublished - Mar 1 2018

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Attention Deficit Disorder with Hyperactivity
Sleep
Habits
Placebos
Autism Spectrum Disorder
Atomoxetine Hydrochloride
Caregivers
Randomized Controlled Trials
Education
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Hollway, Jill A. ; Mendoza-Burcham, Marissa Imee ; Andridge, Rebecca ; Aman, Michael G. ; Handen, Benjamin ; Arnold, L. Eugene ; Lecavalier, Luc ; Williams, Craig ; Silverman, Laura ; Smith, Tristram. / Atomoxetine, Parent Training, and Their Effects on Sleep in Youth with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder. In: Journal of Child and Adolescent Psychopharmacology. 2018 ; Vol. 28, No. 2. pp. 130-135.
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Hollway, JA, Mendoza-Burcham, MI, Andridge, R, Aman, MG, Handen, B, Arnold, LE, Lecavalier, L, Williams, C, Silverman, L & Smith, T 2018, 'Atomoxetine, Parent Training, and Their Effects on Sleep in Youth with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder', Journal of Child and Adolescent Psychopharmacology, vol. 28, no. 2, pp. 130-135. https://doi.org/10.1089/cap.2017.0085

Atomoxetine, Parent Training, and Their Effects on Sleep in Youth with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder. / Hollway, Jill A.; Mendoza-Burcham, Marissa Imee; Andridge, Rebecca; Aman, Michael G.; Handen, Benjamin; Arnold, L. Eugene; Lecavalier, Luc; Williams, Craig; Silverman, Laura; Smith, Tristram.

In: Journal of Child and Adolescent Psychopharmacology, Vol. 28, No. 2, 01.03.2018, p. 130-135.

Research output: Contribution to journalArticle

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AU - Andridge, Rebecca

AU - Aman, Michael G.

AU - Handen, Benjamin

AU - Arnold, L. Eugene

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AU - Williams, Craig

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AU - Smith, Tristram

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N2 - Objective: Sleep disturbance is often a problem for children with either autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD). Psychostimulant medications used to treat ADHD symptoms can exacerbate this problem. For children with ASD and ADHD, atomoxetine (ATX) is a viable alternative to psychostimulants. We investigated the effects of ATX and a manualized parent training (PT) program targeting noncompliance, on the sleep quality of children with ASD and ADHD. Methods: Participants in a randomized clinical trial were treated with ATX + PT, ATX alone, PT alone, or placebo (PBO) alone, for 10 weeks. Fifty-four of 128 (42%) caregivers completed the Children's Sleep Habits Questionnaire (CSHQ) at baseline and endpoint. Analysis of covariance was used to investigate possible differences between treatment groups. Results: There were no significant differences between treatment groups, including PBO on the CSHQ 33-Item total score, total hours of sleep per day, and total minutes awake after sleep onset at the study endpoint. Conclusion: ATX appears sleep neutral. Clinicians who treat ADHD symptoms in children and adolescents with ASD may prefer ATX over psychostimulants when sleep disturbance is an issue.

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