TY - JOUR
T1 - Attachment and telomere length
T2 - more evidence for psychobiological connections between close relationships, health, and aging
AU - Murdock, Kyle W.
AU - Zilioli, Samuele
AU - Ziauddin, Khadija
AU - Heijnen, Cobi J.
AU - Fagundes, Christopher P.
N1 - Funding Information:
Acknowledgements The data used for this article were collected by the Laboratory for the Study of Stress, Immunity, and Disease at Carnegie Mellon University under the directorship of Sheldon Cohen, PhD; and were accessed via the Common Cold Project (CCP) website (www.commoncoldproject.com). CCP data are made publically available through a grant from the National Center for Complementary and Integrative Health (AT006694); the conduct of the studies was supported by grants from the National Heart, Lung, and Blood Institute (HL65111; HL65112) and National Institute for Allergy and Infectious Diseases (R01 AI066367); secondary support was provided by a grant from the National Institutes of Health to the University of Pittsburgh Clinical and Translational Science Institute (UL1 RR024153 and UL1 RT000005); and supplemental support was provided by John D. and Catherine T. MacArthur Foundation Research Network on Socioeconomic Status and Health. Preparation of the manuscript was supported by the National Heart, Lung, and Blood Institute (R01HL127260; F32HL131353).
Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Individuals with a history of poor interpersonal relationships are more likely to demonstrate negative health outcomes than those who have had high quality relationships. We sought to evaluate how attachment orientations, stress-induced respiratory sinus arrhythmia (RSA), and self-reported stress were associated with length of telomeres measured from peripheral blood mononuclear cells. Participants (N = 213) completed self-report measures of attachment and stress. Measurement of RSA was conducted before and after a stressful task and a blood draw was completed for analysis of telomere length. Attachment orientations were not directly associated with telomere length; however, we found that high attachment anxiety was associated with shorter length of telomeres via high self-reported stress. Attachment avoidance was also associated with telomere length via self-reported stress, but only among those with high stress-induced RSA. Exploratory analyses of T cell subsets indicated that stress was most strongly associated with telomeres from CD8CD28+ cells in comparison to CD8CD28− and CD4 cells. Study findings indicate that attachment orientations are associated with telomere length via stress, providing novel insights into the mechanisms through which close relationships can impact health and aging.
AB - Individuals with a history of poor interpersonal relationships are more likely to demonstrate negative health outcomes than those who have had high quality relationships. We sought to evaluate how attachment orientations, stress-induced respiratory sinus arrhythmia (RSA), and self-reported stress were associated with length of telomeres measured from peripheral blood mononuclear cells. Participants (N = 213) completed self-report measures of attachment and stress. Measurement of RSA was conducted before and after a stressful task and a blood draw was completed for analysis of telomere length. Attachment orientations were not directly associated with telomere length; however, we found that high attachment anxiety was associated with shorter length of telomeres via high self-reported stress. Attachment avoidance was also associated with telomere length via self-reported stress, but only among those with high stress-induced RSA. Exploratory analyses of T cell subsets indicated that stress was most strongly associated with telomeres from CD8CD28+ cells in comparison to CD8CD28− and CD4 cells. Study findings indicate that attachment orientations are associated with telomere length via stress, providing novel insights into the mechanisms through which close relationships can impact health and aging.
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U2 - 10.1007/s10865-017-9895-2
DO - 10.1007/s10865-017-9895-2
M3 - Article
C2 - 29067540
AN - SCOPUS:85032012538
VL - 41
SP - 333
EP - 343
JO - Journal of Behavioral Medicine
JF - Journal of Behavioral Medicine
SN - 0160-7715
IS - 3
ER -