Attention and executive function are impaired during active standing in postural tachycardia syndrome

Amanda J. Miller, Timothy Sheehan, Kate M. Bourne, Monica Feeley, Amy C. Arnold

Research output: Contribution to journalArticle

Abstract

Postural tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance associated with cognitive dysfunction. We hypothesized executive function and attention is impaired in POTS during active standing. Eighty-seven POTS participants and 39 healthy controls of similar age, sex, and education level completed executive function (Stroop word-color) and attention (CogState Identification) tests in supine and standing postures in a cross-sectional study. POTS participants had lower executive function (t-score: 48 ± 11 vs. 55 ± 10 control; p = 0.009) and worse attention (reaction speed: 2.78 ± 0.11 vs. 2.69 ± 0.06 control; p < 0.001) during standing. These data provide new evidence that active standing impairs attention and executive functioning in POTS.

Original languageEnglish (US)
Article number102692
JournalAutonomic Neuroscience: Basic and Clinical
Volume227
DOIs
StatePublished - Sep 2020

All Science Journal Classification (ASJC) codes

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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