Attenuation of the pressor response to tracheal intubation by magnesium sulphate with and without alfentanil in hypertensive proteinuric patients undergoing caesarean section

W. B. Ashton, M. F.M. James, P. Janicki, P. C. Uys

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62 Scopus citations

Abstract

The pressor response to tracheal intubation is known to be exaggerated in patients with gestational proteinuric hypertension (GPH). We have studied the effect of pretreatment with magnesium sulphate 40 mg kg- or 30 mg kg- with alfentanil 7.5 μlg kg- on this pressor response in 38 patients with moderate to severe GPH. The magnesium-alfentanil combination produced better control of arterial pressure and heart rate than magnesium alone, although both techniques provided good cardiovascular control. There was no significant difference in fetal outcome between1 groups. Both pretreatment methods produced satisfactory control of catecholamine release.

Original languageEnglish (US)
Pages (from-to)741-747
Number of pages7
JournalBritish Journal of Anaesthesia
Volume67
Issue number6
DOIs
StatePublished - Dec 1991

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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