Atypical antipsychotic medication and substance use-related outcomes in the treatment of schizophrenia

Ismene L. Petrakis, Douglas Leslie, John W. Finney, Robert Rosenheck

Research output: Contribution to journalArticle

23 Scopus citations


Using national administrative data from the Department of Veterans Affairs (VA), clinical change in veterans with schizophrenia and comorbid substance abuse and dependence (n=249) was assessed with the Addiction Severity Index. Outcomes among those switched or maintained on an atypical antipsychotic were compared with those treated with conventionals. For the entire sample and those on an atypical during the last assessment, paired t-tests showed significant decreases in the alcohol and psychological ASI scores. However, multivariate analysis showed no greater improvement in alcohol, drug, or psychological scores in individuals who were switched to (n=33) or maintained on (n = 161) an atypical antipsychotic as compared to those who were treated with conventional at the final assessment (n = 55). Patients treated with atypical antipsychotics achieved no greater improvement in substance-related outcomes that patients who were not.

Original languageEnglish (US)
Pages (from-to)44-49
Number of pages6
JournalAmerican Journal on Addictions
Issue number1
Publication statusPublished - Feb 14 2006


All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

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