Atypical lobular hyperplasia and lobular carcinoma in situ at core needle biopsy of the breast: An incidental finding or are there characteristic imaging findings?

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Abstract

Background: Atypical lobular hyperplasia and classic-type lobular carcinoma in situ, collectively known as lobular neoplasia, are classically described as incidental findings found on breast core-needle biopsy without distinguishing imaging characteristics. OBJECTIVE: The purpose of this study was to investigate concordant imaging findings of lobular neoplasia identified at coreneedle biopsy after careful radiologic-pathologic correlation. METHODS: The pathology database was searched from October 1, 2006 to October 1, 2013 for breast biopsies yielding lobular neoplasia not associated with a coexistent malignancy or other high risk lesion in the biopsy specimen. RESULTS: Of the 482 biopsies performed containing lobular neoplasia, 65 cases had lobular neoplasia as the highest risk lesion at core-needle biopsy. Of the 65 total cases in which lobular neoplasia was the highest risk lesion, 18 (28%) cases had concordant imaging correlates. 13 of 18 (72%) cases presented as calcifications on mammography and 5 of 18 (28%) presented on magnetic resonance imaging as a focus (n = 2) or non-mass enhancement (n = 3). CONCLUSION: With careful radiologic-pathologic correlation, mammographically detected calcifications and foci or nonmass enhancement on magnetic resonance imaging can be considered concordant imaging findings of lobular neoplasia after breast core-needle biopsy.

Original languageEnglish (US)
Pages (from-to)5-14
Number of pages10
JournalBreast Disease
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2016

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Large-Core Needle Biopsy
Incidental Findings
Hyperplasia
Breast
Neoplasms
Biopsy
Magnetic Resonance Imaging
Breast Carcinoma In Situ
Mammography
Databases
Pathology

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

@article{c09f9fd2e2ad4feda26b6edde639b5ba,
title = "Atypical lobular hyperplasia and lobular carcinoma in situ at core needle biopsy of the breast: An incidental finding or are there characteristic imaging findings?",
abstract = "Background: Atypical lobular hyperplasia and classic-type lobular carcinoma in situ, collectively known as lobular neoplasia, are classically described as incidental findings found on breast core-needle biopsy without distinguishing imaging characteristics. OBJECTIVE: The purpose of this study was to investigate concordant imaging findings of lobular neoplasia identified at coreneedle biopsy after careful radiologic-pathologic correlation. METHODS: The pathology database was searched from October 1, 2006 to October 1, 2013 for breast biopsies yielding lobular neoplasia not associated with a coexistent malignancy or other high risk lesion in the biopsy specimen. RESULTS: Of the 482 biopsies performed containing lobular neoplasia, 65 cases had lobular neoplasia as the highest risk lesion at core-needle biopsy. Of the 65 total cases in which lobular neoplasia was the highest risk lesion, 18 (28{\%}) cases had concordant imaging correlates. 13 of 18 (72{\%}) cases presented as calcifications on mammography and 5 of 18 (28{\%}) presented on magnetic resonance imaging as a focus (n = 2) or non-mass enhancement (n = 3). CONCLUSION: With careful radiologic-pathologic correlation, mammographically detected calcifications and foci or nonmass enhancement on magnetic resonance imaging can be considered concordant imaging findings of lobular neoplasia after breast core-needle biopsy.",
author = "Barry Amos and Alison Chetlen and Nicole Williams",
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doi = "10.3233/BD-150194",
language = "English (US)",
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pages = "5--14",
journal = "Breast Disease",
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T1 - Atypical lobular hyperplasia and lobular carcinoma in situ at core needle biopsy of the breast

T2 - An incidental finding or are there characteristic imaging findings?

AU - Amos, Barry

AU - Chetlen, Alison

AU - Williams, Nicole

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: Atypical lobular hyperplasia and classic-type lobular carcinoma in situ, collectively known as lobular neoplasia, are classically described as incidental findings found on breast core-needle biopsy without distinguishing imaging characteristics. OBJECTIVE: The purpose of this study was to investigate concordant imaging findings of lobular neoplasia identified at coreneedle biopsy after careful radiologic-pathologic correlation. METHODS: The pathology database was searched from October 1, 2006 to October 1, 2013 for breast biopsies yielding lobular neoplasia not associated with a coexistent malignancy or other high risk lesion in the biopsy specimen. RESULTS: Of the 482 biopsies performed containing lobular neoplasia, 65 cases had lobular neoplasia as the highest risk lesion at core-needle biopsy. Of the 65 total cases in which lobular neoplasia was the highest risk lesion, 18 (28%) cases had concordant imaging correlates. 13 of 18 (72%) cases presented as calcifications on mammography and 5 of 18 (28%) presented on magnetic resonance imaging as a focus (n = 2) or non-mass enhancement (n = 3). CONCLUSION: With careful radiologic-pathologic correlation, mammographically detected calcifications and foci or nonmass enhancement on magnetic resonance imaging can be considered concordant imaging findings of lobular neoplasia after breast core-needle biopsy.

AB - Background: Atypical lobular hyperplasia and classic-type lobular carcinoma in situ, collectively known as lobular neoplasia, are classically described as incidental findings found on breast core-needle biopsy without distinguishing imaging characteristics. OBJECTIVE: The purpose of this study was to investigate concordant imaging findings of lobular neoplasia identified at coreneedle biopsy after careful radiologic-pathologic correlation. METHODS: The pathology database was searched from October 1, 2006 to October 1, 2013 for breast biopsies yielding lobular neoplasia not associated with a coexistent malignancy or other high risk lesion in the biopsy specimen. RESULTS: Of the 482 biopsies performed containing lobular neoplasia, 65 cases had lobular neoplasia as the highest risk lesion at core-needle biopsy. Of the 65 total cases in which lobular neoplasia was the highest risk lesion, 18 (28%) cases had concordant imaging correlates. 13 of 18 (72%) cases presented as calcifications on mammography and 5 of 18 (28%) presented on magnetic resonance imaging as a focus (n = 2) or non-mass enhancement (n = 3). CONCLUSION: With careful radiologic-pathologic correlation, mammographically detected calcifications and foci or nonmass enhancement on magnetic resonance imaging can be considered concordant imaging findings of lobular neoplasia after breast core-needle biopsy.

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