Augmentation of antibody responses by retinoic acid and costimulatory molecules

A. Catharine Ross, Qiuyan Chen, Yifan Ma

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Antibody production is crucial for a successful vaccine response. Beyond the ability of vitamin A (VA) and its active metabolite, all-trans-retinoic acid (RA) to restore growth in VA-deficient animals, supplementation with VA and/or treatment with RA can augment antibody responses in both VA-deficient and VA-adequate animals. RA alone, and in combination with stimuli that are ligands for the Toll-like receptor family, can augment the adaptive immune response leading to a heightened primary antibody response, and a stronger recall response upon restimulation. Mechanisms may include regulation of cell populations, type 1/type 2 cytokines, and B cell-related transcription factors, leading to accelerated B cell maturation.

Original languageEnglish (US)
Pages (from-to)42-50
Number of pages9
JournalSeminars in Immunology
Volume21
Issue number1
DOIs
StatePublished - Feb 1 2009

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Tretinoin
Vitamin A
Antibody Formation
B-Lymphocytes
Toll-Like Receptors
Adaptive Immunity
Transcription Factors
Vaccines
Cytokines
Ligands
Growth
Population

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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Augmentation of antibody responses by retinoic acid and costimulatory molecules. / Ross, A. Catharine; Chen, Qiuyan; Ma, Yifan.

In: Seminars in Immunology, Vol. 21, No. 1, 01.02.2009, p. 42-50.

Research output: Contribution to journalReview article

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