Autoantibody profiles in two patients with non-autoimmune muscle disease implicate a role for gliadin autoreactivity

Nancy Olsen, Heidi Prather, Quan Zhen Li, Dennis K. Burns

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The objective of this case study was to characterize autoreactivity in two patients with non-autoimmune forms of muscle disease who had positivity for antinuclear antibodies (ANA) and Ro (SSA) autoantibodies. Serum samples from these two patients were applied to an autoantigen protein array with more than 70 specificities and were compared to samples from healthy controls and patients with systemic lupus erythematosus. Both myopathy patients had high levels of gliadin autoreactivity in serum and one patient had an overall autoantibody profile with lupus-like features. The findings suggest that some disorders of muscle that are considered non-autoimmune, may in fact have autoimmune features. Further examination of the role of subclinical gluten autoreactivity in the pathogenesis of myopathy syndromes has the potential to suggest improved approaches to diagnosis and treatment of these conditions.

Original languageEnglish (US)
Pages (from-to)188-191
Number of pages4
JournalNeuromuscular Disorders
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2010

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Gliadin
Autoantibodies
Muscular Diseases
Muscles
Protein Array Analysis
Glutens
Antinuclear Antibodies
Serum
Systemic Lupus Erythematosus

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Clinical Neurology
  • Genetics(clinical)

Cite this

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abstract = "The objective of this case study was to characterize autoreactivity in two patients with non-autoimmune forms of muscle disease who had positivity for antinuclear antibodies (ANA) and Ro (SSA) autoantibodies. Serum samples from these two patients were applied to an autoantigen protein array with more than 70 specificities and were compared to samples from healthy controls and patients with systemic lupus erythematosus. Both myopathy patients had high levels of gliadin autoreactivity in serum and one patient had an overall autoantibody profile with lupus-like features. The findings suggest that some disorders of muscle that are considered non-autoimmune, may in fact have autoimmune features. Further examination of the role of subclinical gluten autoreactivity in the pathogenesis of myopathy syndromes has the potential to suggest improved approaches to diagnosis and treatment of these conditions.",
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Autoantibody profiles in two patients with non-autoimmune muscle disease implicate a role for gliadin autoreactivity. / Olsen, Nancy; Prather, Heidi; Li, Quan Zhen; Burns, Dennis K.

In: Neuromuscular Disorders, Vol. 20, No. 3, 01.03.2010, p. 188-191.

Research output: Contribution to journalArticle

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