Autoimmune pancytopenia of childhood associated with multisystem disease manifestations

Barbara Miller, Diana Schultz Beardsley

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Five patients with immune thrombocytopenia and neutropenia, including three with autoimmune hemolytic anemia, are described; none had identifiable underlying disease. All patients had demonstrable autoantibodies against multiple hematopoietic cell types, and in two patients, the antiplatelet and antierythrocyte antibodies were shown to be distinct. All patients had continuing disease, and with follow-up of 2 to 6 1/2 years, all developed nonhematologic disease manifestations. These patients demonstrate that even in the absence of identifiable underlying disease, autoimmune hematologic disease resulting from production of antibodies against red cells, white cells, and platelets often involves a generalized disorder of immune regulation, with multisystem disease manifestations and a prolonged course.

Original languageEnglish (US)
Pages (from-to)877-881
Number of pages5
JournalThe Journal of pediatrics
Volume103
Issue number6
DOIs
StatePublished - Jan 1 1983

Fingerprint

Pancytopenia
Autoimmune Hemolytic Anemia
Idiopathic Thrombocytopenic Purpura
Hematologic Diseases
Immune System Diseases
Neutropenia
Autoantibodies
Autoimmune Diseases
Antibody Formation
Blood Platelets
Antibodies

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

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Autoimmune pancytopenia of childhood associated with multisystem disease manifestations. / Miller, Barbara; Beardsley, Diana Schultz.

In: The Journal of pediatrics, Vol. 103, No. 6, 01.01.1983, p. 877-881.

Research output: Contribution to journalArticle

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