Autoimmunity in immunodeficiency

Krista Todoric, Jessica B. Koontz, Daniel Mattox, Teresa K. Tarrant

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Primary immunodeficiencies (PID) comprise a diverse group of clinical disorders with varied genetic defects. Paradoxically, a substantial proportion of PID patients develop autoimmune phenomena in addition to having increased susceptibility to infections from their impaired immunity. Although much of our understanding comes from data gathered through experimental models, there are several well-characterized PID that have improved our knowledge of the pathways that drive autoimmunity. The goals of this review will be to discuss these immunodeficiencies and to review the literature with respect to the proposed mechanisms for autoimmunity within each put forth to date.

Original languageEnglish (US)
Pages (from-to)361-370
Number of pages10
JournalCurrent Allergy and Asthma Reports
Volume13
Issue number4
DOIs
StatePublished - Aug 2013

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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    Todoric, K., Koontz, J. B., Mattox, D., & Tarrant, T. K. (2013). Autoimmunity in immunodeficiency. Current Allergy and Asthma Reports, 13(4), 361-370. https://doi.org/10.1007/s11882-013-0350-3