Autoimmunity in immunodeficiency

Krista Todoric, Jessica B. Koontz, Daniel Mattox, Teresa K. Tarrant

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Primary immunodeficiencies (PID) comprise a diverse group of clinical disorders with varied genetic defects. Paradoxically, a substantial proportion of PID patients develop autoimmune phenomena in addition to having increased susceptibility to infections from their impaired immunity. Although much of our understanding comes from data gathered through experimental models, there are several well-characterized PID that have improved our knowledge of the pathways that drive autoimmunity. The goals of this review will be to discuss these immunodeficiencies and to review the literature with respect to the proposed mechanisms for autoimmunity within each put forth to date.

Original languageEnglish (US)
Pages (from-to)361-370
Number of pages10
JournalCurrent Allergy and Asthma Reports
Volume13
Issue number4
DOIs
StatePublished - Aug 1 2013

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Autoimmunity
Immunity
Theoretical Models
Infection

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

Todoric, Krista ; Koontz, Jessica B. ; Mattox, Daniel ; Tarrant, Teresa K. / Autoimmunity in immunodeficiency. In: Current Allergy and Asthma Reports. 2013 ; Vol. 13, No. 4. pp. 361-370.
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Todoric, K, Koontz, JB, Mattox, D & Tarrant, TK 2013, 'Autoimmunity in immunodeficiency', Current Allergy and Asthma Reports, vol. 13, no. 4, pp. 361-370. https://doi.org/10.1007/s11882-013-0350-3

Autoimmunity in immunodeficiency. / Todoric, Krista; Koontz, Jessica B.; Mattox, Daniel; Tarrant, Teresa K.

In: Current Allergy and Asthma Reports, Vol. 13, No. 4, 01.08.2013, p. 361-370.

Research output: Contribution to journalArticle

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