Autophagy and apoptosis: Rivals or mates?

Yan Cheng, Jin Ming Yang

Research output: Contribution to journalEditorialpeer-review

7 Scopus citations

Abstract

Autophagy, a cellular process of "self-eating" by which intracellular components are degraded within the lysosome, is an evolutionary conserved response to various stresses. Autophagy is associated with numerous patho-ph ysiological conditions, and dysregulation of autophagy contributes to the pathogenesis of a variety of human diseases including cancer. Depending on context, activation of autophagy may promote either cell survival or death, two major events that determine pathological process of many illnesses. Importantly, the activity of autophagy is often associated with apoptosis, another critical cellular process determining cellular fate. A better understanding of biology of autophagy and its implication in human health and disorder, as well as the relationship between autophagy and apoptosis, has the potential of facilitating the development of autophagy-based therapeutic interventions for human diseases such as cancer.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalChinese Journal of Cancer
Volume32
Issue number3
DOIs
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Oncology

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