Autotomy in rats after peripheral nerve section: Lack of effect of topical nerve or neonatal capsaicin treatment

J. I. Nagy, M. Buss, Brenda Mallory

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The influence of capsaicin on autotomy was studied in adult rats in which the sciatic and saphenous nerves were sectioned. Capsaicin was administered subcutaneously to neonatal rats or applied topically to the sciatic and saphenous nerves in adult animals. Quantification of neurogenic plasma extravasation in skin areas subserved by these nerves and of the number of small type B neurones in lumbar sensory ganglia were used to confirm the effectiveness of capsaicin-induced lesions of unmyelinated sensory nerves. Neonatal capsaicin treatment significantly reduced neuronal numbers in ganglia and, compared to control responses, plasma extravasation was nearly abolished after both neonatal and peripheral nerve treatment with capsaicin. Despite these deficits in sensory neurones function, no differences in any parameters of autotomy were observed between animals receiving both capsaicin treatment and nerve section and those given nerve section alone. Animals in both control and experimental groups exhibited high autotomy scores. These results suggest that capsaicin-sensitive primary sensory neurones do not have a significant role in precipitating autotomy characterized by high incidence and severity.

Original languageEnglish (US)
Pages (from-to)75-86
Number of pages12
JournalPain
Volume24
Issue number1
DOIs
StatePublished - Jan 1 1986

Fingerprint

Capsaicin
Peripheral Nerves
Sensory Receptor Cells
Sciatic Nerve
Therapeutics
Sensory Ganglia
Ganglia
Neurons
Control Groups
Skin
Incidence

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

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abstract = "The influence of capsaicin on autotomy was studied in adult rats in which the sciatic and saphenous nerves were sectioned. Capsaicin was administered subcutaneously to neonatal rats or applied topically to the sciatic and saphenous nerves in adult animals. Quantification of neurogenic plasma extravasation in skin areas subserved by these nerves and of the number of small type B neurones in lumbar sensory ganglia were used to confirm the effectiveness of capsaicin-induced lesions of unmyelinated sensory nerves. Neonatal capsaicin treatment significantly reduced neuronal numbers in ganglia and, compared to control responses, plasma extravasation was nearly abolished after both neonatal and peripheral nerve treatment with capsaicin. Despite these deficits in sensory neurones function, no differences in any parameters of autotomy were observed between animals receiving both capsaicin treatment and nerve section and those given nerve section alone. Animals in both control and experimental groups exhibited high autotomy scores. These results suggest that capsaicin-sensitive primary sensory neurones do not have a significant role in precipitating autotomy characterized by high incidence and severity.",
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Autotomy in rats after peripheral nerve section : Lack of effect of topical nerve or neonatal capsaicin treatment. / Nagy, J. I.; Buss, M.; Mallory, Brenda.

In: Pain, Vol. 24, No. 1, 01.01.1986, p. 75-86.

Research output: Contribution to journalArticle

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AB - The influence of capsaicin on autotomy was studied in adult rats in which the sciatic and saphenous nerves were sectioned. Capsaicin was administered subcutaneously to neonatal rats or applied topically to the sciatic and saphenous nerves in adult animals. Quantification of neurogenic plasma extravasation in skin areas subserved by these nerves and of the number of small type B neurones in lumbar sensory ganglia were used to confirm the effectiveness of capsaicin-induced lesions of unmyelinated sensory nerves. Neonatal capsaicin treatment significantly reduced neuronal numbers in ganglia and, compared to control responses, plasma extravasation was nearly abolished after both neonatal and peripheral nerve treatment with capsaicin. Despite these deficits in sensory neurones function, no differences in any parameters of autotomy were observed between animals receiving both capsaicin treatment and nerve section and those given nerve section alone. Animals in both control and experimental groups exhibited high autotomy scores. These results suggest that capsaicin-sensitive primary sensory neurones do not have a significant role in precipitating autotomy characterized by high incidence and severity.

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