Avian and human influenza virus compatible sialic acid receptors in little brown bats

Shubhada K. Chothe, Gitanjali Bhushan, Ruth H. Nissly, Yin-Ting Yeh, Justin David Brown, Gregory Turner, Jenny Suzanne Fisher, Brent J. Sewall, Deeann M. Reeder, Mauricio Terrones Maldonado, Bhushan M. Jayarao, Suresh Varma Kuchipudi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Influenza A viruses (IAVs) continue to threaten animal and human health globally. Bats are asymptomatic reservoirs for many zoonotic viruses. Recent reports of two novel IAVs in fruit bats and serological evidence of avian influenza virus (AIV) H9 infection in frugivorous bats raise questions about the role of bats in IAV epidemiology. IAVs bind to sialic acid (SA) receptors on host cells, and it is widely believed that hosts expressing both SA α2,3-Gal and SA α2,6-Gal receptors could facilitate genetic reassortment of avian and human IAVs. We found abundant co-expression of both avian (SA α2,3-Gal) and human (SA α2,6-Gal) type SA receptors in little brown bats (LBBs) that were compatible with avian and human IAV binding. This first ever study of IAV receptors in a bat species suggest that LBBs, a widely-distributed bat species in North America, could potentially be co-infected with avian and human IAVs, facilitating the emergence of zoonotic strains.

Original languageEnglish (US)
Article number793
JournalScientific reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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Influenza in Birds
Influenza A virus
Orthomyxoviridae
Human Influenza
N-Acetylneuraminic Acid
Zoonoses
Virus Receptors
Virus Attachment
sialic acid receptor
Virus Diseases
North America
Fruit
Epidemiology
Viruses
Health

All Science Journal Classification (ASJC) codes

  • General

Cite this

Chothe, Shubhada K. ; Bhushan, Gitanjali ; Nissly, Ruth H. ; Yeh, Yin-Ting ; Brown, Justin David ; Turner, Gregory ; Fisher, Jenny Suzanne ; Sewall, Brent J. ; Reeder, Deeann M. ; Terrones Maldonado, Mauricio ; Jayarao, Bhushan M. ; Kuchipudi, Suresh Varma. / Avian and human influenza virus compatible sialic acid receptors in little brown bats. In: Scientific reports. 2017 ; Vol. 7, No. 1.
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Avian and human influenza virus compatible sialic acid receptors in little brown bats. / Chothe, Shubhada K.; Bhushan, Gitanjali; Nissly, Ruth H.; Yeh, Yin-Ting; Brown, Justin David; Turner, Gregory; Fisher, Jenny Suzanne; Sewall, Brent J.; Reeder, Deeann M.; Terrones Maldonado, Mauricio; Jayarao, Bhushan M.; Kuchipudi, Suresh Varma.

In: Scientific reports, Vol. 7, No. 1, 793, 01.12.2017.

Research output: Contribution to journalArticle

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