Avian oncogenesis induced by lymphoproliferative disease virus: A neglected or emerging retroviral pathogen?

Andrew B. Allison, M. Kevin Keel, Jamie E. Philips, Andrew N. Cartoceti, Brandon A. Munk, Nicole M. Nemeth, Trista I. Welsh, Jesse M. Thomas, James M. Crum, Anne B. Lichtenwalner, Aly M. Fadly, Guillermo Zavala, Edward C. Holmes, Justin David Brown

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Lymphoproliferative disease virus (LPDV) is an exogenous oncogenic retrovirus that induces lymphoid tumors in some galliform species of birds. Historically, outbreaks of LPDV have been reported from Europe and Israel. Although the virus has previously never been detected in North America, herein we describe the widespread distribution, genetic diversity, pathogenesis, and evolution of LPDV in the United States. Characterization of the provirus genome of the index LPDV case from North America demonstrated an 88% nucleotide identity to the Israeli prototype strain. Although phylogenetic analysis indicated that the majority of viruses fell into a single North American lineage, a small subset of viruses from South Carolina were most closely related to the Israeli prototype. These results suggest that LPDV was transferred between continents to initiate outbreaks of disease. However, the direction (New World to Old World or vice versa), mechanism, and time frame of the transcontinental spread currently remain unknown.

Original languageEnglish (US)
Pages (from-to)2-12
Number of pages11
JournalVirology
Volume450-451
DOIs
StatePublished - Feb 1 2014

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Gammaherpesvirinae
Carcinogenesis
North America
Viruses
Disease Outbreaks
Proviruses
Molecular Evolution
Israel
Retroviridae
Birds
Nucleotides
Genome

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

Allison, A. B., Kevin Keel, M., Philips, J. E., Cartoceti, A. N., Munk, B. A., Nemeth, N. M., ... Brown, J. D. (2014). Avian oncogenesis induced by lymphoproliferative disease virus: A neglected or emerging retroviral pathogen? Virology, 450-451, 2-12. https://doi.org/10.1016/j.virol.2013.11.037
Allison, Andrew B. ; Kevin Keel, M. ; Philips, Jamie E. ; Cartoceti, Andrew N. ; Munk, Brandon A. ; Nemeth, Nicole M. ; Welsh, Trista I. ; Thomas, Jesse M. ; Crum, James M. ; Lichtenwalner, Anne B. ; Fadly, Aly M. ; Zavala, Guillermo ; Holmes, Edward C. ; Brown, Justin David. / Avian oncogenesis induced by lymphoproliferative disease virus : A neglected or emerging retroviral pathogen?. In: Virology. 2014 ; Vol. 450-451. pp. 2-12.
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abstract = "Lymphoproliferative disease virus (LPDV) is an exogenous oncogenic retrovirus that induces lymphoid tumors in some galliform species of birds. Historically, outbreaks of LPDV have been reported from Europe and Israel. Although the virus has previously never been detected in North America, herein we describe the widespread distribution, genetic diversity, pathogenesis, and evolution of LPDV in the United States. Characterization of the provirus genome of the index LPDV case from North America demonstrated an 88{\%} nucleotide identity to the Israeli prototype strain. Although phylogenetic analysis indicated that the majority of viruses fell into a single North American lineage, a small subset of viruses from South Carolina were most closely related to the Israeli prototype. These results suggest that LPDV was transferred between continents to initiate outbreaks of disease. However, the direction (New World to Old World or vice versa), mechanism, and time frame of the transcontinental spread currently remain unknown.",
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Allison, AB, Kevin Keel, M, Philips, JE, Cartoceti, AN, Munk, BA, Nemeth, NM, Welsh, TI, Thomas, JM, Crum, JM, Lichtenwalner, AB, Fadly, AM, Zavala, G, Holmes, EC & Brown, JD 2014, 'Avian oncogenesis induced by lymphoproliferative disease virus: A neglected or emerging retroviral pathogen?', Virology, vol. 450-451, pp. 2-12. https://doi.org/10.1016/j.virol.2013.11.037

Avian oncogenesis induced by lymphoproliferative disease virus : A neglected or emerging retroviral pathogen? / Allison, Andrew B.; Kevin Keel, M.; Philips, Jamie E.; Cartoceti, Andrew N.; Munk, Brandon A.; Nemeth, Nicole M.; Welsh, Trista I.; Thomas, Jesse M.; Crum, James M.; Lichtenwalner, Anne B.; Fadly, Aly M.; Zavala, Guillermo; Holmes, Edward C.; Brown, Justin David.

In: Virology, Vol. 450-451, 01.02.2014, p. 2-12.

Research output: Contribution to journalArticle

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AU - Crum, James M.

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AU - Holmes, Edward C.

AU - Brown, Justin David

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AB - Lymphoproliferative disease virus (LPDV) is an exogenous oncogenic retrovirus that induces lymphoid tumors in some galliform species of birds. Historically, outbreaks of LPDV have been reported from Europe and Israel. Although the virus has previously never been detected in North America, herein we describe the widespread distribution, genetic diversity, pathogenesis, and evolution of LPDV in the United States. Characterization of the provirus genome of the index LPDV case from North America demonstrated an 88% nucleotide identity to the Israeli prototype strain. Although phylogenetic analysis indicated that the majority of viruses fell into a single North American lineage, a small subset of viruses from South Carolina were most closely related to the Israeli prototype. These results suggest that LPDV was transferred between continents to initiate outbreaks of disease. However, the direction (New World to Old World or vice versa), mechanism, and time frame of the transcontinental spread currently remain unknown.

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Allison AB, Kevin Keel M, Philips JE, Cartoceti AN, Munk BA, Nemeth NM et al. Avian oncogenesis induced by lymphoproliferative disease virus: A neglected or emerging retroviral pathogen? Virology. 2014 Feb 1;450-451:2-12. https://doi.org/10.1016/j.virol.2013.11.037