Avpr1a variant associated with preschoolers' lower altruistic behavior

Reut Avinun, Salomon Israel, Idan Shalev, Inga Gritsenko, Gary Bornstein, Richard P. Ebstein, Ariel Knafo

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The genetic origins of altruism, defined here as a costly act aimed to benefit non-kin individuals, have not been examined in young children. However, previous findings concerning adults pointed at the arginine vasopressin receptor 1A (AVPR1A) gene as a possible candidate. AVPR1A has been associated with a range of behaviors including aggressive, affiliative and altruistic phenotypes, and recently a specific allele (327 bp) of one of its promoter region polymorphisms (RS3) has been singled out in particular. We modeled altruistic behavior in preschoolers using a laboratory-based economic paradigm, a modified dictator game (DG), and tested for association between DG allocations and the RS3 "target allele." Using both population and family-based analyses we show a significant link between lower allocations and the RS3 "target allele," associating it, for the first time, with a lower proclivity toward altruistic behavior in children. This finding helps further the understanding of the intricate mechanisms underlying early altruistic behavior.

Original languageEnglish (US)
Article numbere25274
JournalPloS one
Volume6
Issue number9
DOIs
StatePublished - Sep 28 2011

Fingerprint

Vasopressin Receptors
preschool children
arginine vasopressin
Alleles
alleles
Polymorphism
Genetic Promoter Regions
Altruism
altruism
Genes
Child Behavior
Economics
aggression
promoter regions
genetic polymorphism
Phenotype
phenotype
economics
Population
genes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Avinun, R., Israel, S., Shalev, I., Gritsenko, I., Bornstein, G., Ebstein, R. P., & Knafo, A. (2011). Avpr1a variant associated with preschoolers' lower altruistic behavior. PloS one, 6(9), [e25274]. https://doi.org/10.1371/journal.pone.0025274
Avinun, Reut ; Israel, Salomon ; Shalev, Idan ; Gritsenko, Inga ; Bornstein, Gary ; Ebstein, Richard P. ; Knafo, Ariel. / Avpr1a variant associated with preschoolers' lower altruistic behavior. In: PloS one. 2011 ; Vol. 6, No. 9.
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Avinun, R, Israel, S, Shalev, I, Gritsenko, I, Bornstein, G, Ebstein, RP & Knafo, A 2011, 'Avpr1a variant associated with preschoolers' lower altruistic behavior', PloS one, vol. 6, no. 9, e25274. https://doi.org/10.1371/journal.pone.0025274

Avpr1a variant associated with preschoolers' lower altruistic behavior. / Avinun, Reut; Israel, Salomon; Shalev, Idan; Gritsenko, Inga; Bornstein, Gary; Ebstein, Richard P.; Knafo, Ariel.

In: PloS one, Vol. 6, No. 9, e25274, 28.09.2011.

Research output: Contribution to journalArticle

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Avinun R, Israel S, Shalev I, Gritsenko I, Bornstein G, Ebstein RP et al. Avpr1a variant associated with preschoolers' lower altruistic behavior. PloS one. 2011 Sep 28;6(9). e25274. https://doi.org/10.1371/journal.pone.0025274