Aye-aye population genomic analyses highlight an important center of endemism in northern Madagascar

George H. Perry, Edward E. Louis, Aakrosh Ratan, Oscar C. Bedoya-Reina, Richard C. Burhans, Runhua Lei, Steig E. Johnson, Stephan C. Schuster, Webb Miller

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We performed a population genomics study of the aye-aye, a highly specialized nocturnal lemur from Madagascar. Aye-ayes have low population densities and extensive range requirements that could make this flagship species particularly susceptible to extinction. Therefore, knowledge of genetic diversity and differentiation among aye-aye populations is critical for conservation planning. Such information may also advance our general understanding of Malagasy biogeography, as aye-ayes have the largest species distribution of any lemur. We generated and analyzed whole-genome sequence data for 12 aye-ayes from three regions of Madagascar (North, West, and East). We found that the North population is genetically distinct, with strong differentiation from other aye-ayes over relatively short geographic distances. For comparison, the average FST value between the North and East aye-aye populations - separated by only 248 km - is over 2.1-times greater than that observed between human Africans and Europeans. This finding is consistent with prior watershed- and climate-based hypotheses of a center of endemism in northern Madagascar. Taken together, these results suggest a strong and long-term biogeogra-phical barrier to gene flow. Thus, the specific attention that should be directed toward preserving large, contiguous aye-aye habitats in northern Madagascar may also benefit the conservation of other distinct taxonomic units. To help facilitate future ecological- and conservation- motivated population genomic analyses by noncom-putational biologists, the analytical toolkit used in this study is available on the Galaxy Web site.

Original languageEnglish (US)
Pages (from-to)5823-5828
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number15
DOIs
StatePublished - Apr 9 2013

Fingerprint

Madagascar
Metagenomics
Lemur
Galaxies
Population
Gene Flow
Population Density
Climate
Ecosystem
Genome

All Science Journal Classification (ASJC) codes

  • General

Cite this

Perry, George H. ; Louis, Edward E. ; Ratan, Aakrosh ; Bedoya-Reina, Oscar C. ; Burhans, Richard C. ; Lei, Runhua ; Johnson, Steig E. ; Schuster, Stephan C. ; Miller, Webb. / Aye-aye population genomic analyses highlight an important center of endemism in northern Madagascar. In: Proceedings of the National Academy of Sciences of the United States of America. 2013 ; Vol. 110, No. 15. pp. 5823-5828.
@article{af29a2918b944618a3bb6d259d6bafa7,
title = "Aye-aye population genomic analyses highlight an important center of endemism in northern Madagascar",
abstract = "We performed a population genomics study of the aye-aye, a highly specialized nocturnal lemur from Madagascar. Aye-ayes have low population densities and extensive range requirements that could make this flagship species particularly susceptible to extinction. Therefore, knowledge of genetic diversity and differentiation among aye-aye populations is critical for conservation planning. Such information may also advance our general understanding of Malagasy biogeography, as aye-ayes have the largest species distribution of any lemur. We generated and analyzed whole-genome sequence data for 12 aye-ayes from three regions of Madagascar (North, West, and East). We found that the North population is genetically distinct, with strong differentiation from other aye-ayes over relatively short geographic distances. For comparison, the average FST value between the North and East aye-aye populations - separated by only 248 km - is over 2.1-times greater than that observed between human Africans and Europeans. This finding is consistent with prior watershed- and climate-based hypotheses of a center of endemism in northern Madagascar. Taken together, these results suggest a strong and long-term biogeogra-phical barrier to gene flow. Thus, the specific attention that should be directed toward preserving large, contiguous aye-aye habitats in northern Madagascar may also benefit the conservation of other distinct taxonomic units. To help facilitate future ecological- and conservation- motivated population genomic analyses by noncom-putational biologists, the analytical toolkit used in this study is available on the Galaxy Web site.",
author = "Perry, {George H.} and Louis, {Edward E.} and Aakrosh Ratan and Bedoya-Reina, {Oscar C.} and Burhans, {Richard C.} and Runhua Lei and Johnson, {Steig E.} and Schuster, {Stephan C.} and Webb Miller",
year = "2013",
month = "4",
day = "9",
doi = "10.1073/pnas.1211990110",
language = "English (US)",
volume = "110",
pages = "5823--5828",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "15",

}

Aye-aye population genomic analyses highlight an important center of endemism in northern Madagascar. / Perry, George H.; Louis, Edward E.; Ratan, Aakrosh; Bedoya-Reina, Oscar C.; Burhans, Richard C.; Lei, Runhua; Johnson, Steig E.; Schuster, Stephan C.; Miller, Webb.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 15, 09.04.2013, p. 5823-5828.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Aye-aye population genomic analyses highlight an important center of endemism in northern Madagascar

AU - Perry, George H.

AU - Louis, Edward E.

AU - Ratan, Aakrosh

AU - Bedoya-Reina, Oscar C.

AU - Burhans, Richard C.

AU - Lei, Runhua

AU - Johnson, Steig E.

AU - Schuster, Stephan C.

AU - Miller, Webb

PY - 2013/4/9

Y1 - 2013/4/9

N2 - We performed a population genomics study of the aye-aye, a highly specialized nocturnal lemur from Madagascar. Aye-ayes have low population densities and extensive range requirements that could make this flagship species particularly susceptible to extinction. Therefore, knowledge of genetic diversity and differentiation among aye-aye populations is critical for conservation planning. Such information may also advance our general understanding of Malagasy biogeography, as aye-ayes have the largest species distribution of any lemur. We generated and analyzed whole-genome sequence data for 12 aye-ayes from three regions of Madagascar (North, West, and East). We found that the North population is genetically distinct, with strong differentiation from other aye-ayes over relatively short geographic distances. For comparison, the average FST value between the North and East aye-aye populations - separated by only 248 km - is over 2.1-times greater than that observed between human Africans and Europeans. This finding is consistent with prior watershed- and climate-based hypotheses of a center of endemism in northern Madagascar. Taken together, these results suggest a strong and long-term biogeogra-phical barrier to gene flow. Thus, the specific attention that should be directed toward preserving large, contiguous aye-aye habitats in northern Madagascar may also benefit the conservation of other distinct taxonomic units. To help facilitate future ecological- and conservation- motivated population genomic analyses by noncom-putational biologists, the analytical toolkit used in this study is available on the Galaxy Web site.

AB - We performed a population genomics study of the aye-aye, a highly specialized nocturnal lemur from Madagascar. Aye-ayes have low population densities and extensive range requirements that could make this flagship species particularly susceptible to extinction. Therefore, knowledge of genetic diversity and differentiation among aye-aye populations is critical for conservation planning. Such information may also advance our general understanding of Malagasy biogeography, as aye-ayes have the largest species distribution of any lemur. We generated and analyzed whole-genome sequence data for 12 aye-ayes from three regions of Madagascar (North, West, and East). We found that the North population is genetically distinct, with strong differentiation from other aye-ayes over relatively short geographic distances. For comparison, the average FST value between the North and East aye-aye populations - separated by only 248 km - is over 2.1-times greater than that observed between human Africans and Europeans. This finding is consistent with prior watershed- and climate-based hypotheses of a center of endemism in northern Madagascar. Taken together, these results suggest a strong and long-term biogeogra-phical barrier to gene flow. Thus, the specific attention that should be directed toward preserving large, contiguous aye-aye habitats in northern Madagascar may also benefit the conservation of other distinct taxonomic units. To help facilitate future ecological- and conservation- motivated population genomic analyses by noncom-putational biologists, the analytical toolkit used in this study is available on the Galaxy Web site.

UR - http://www.scopus.com/inward/record.url?scp=84876061150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876061150&partnerID=8YFLogxK

U2 - 10.1073/pnas.1211990110

DO - 10.1073/pnas.1211990110

M3 - Article

VL - 110

SP - 5823

EP - 5828

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 15

ER -