Aye-aye population genomic analyses highlight an important center of endemism in northern Madagascar

George H. Perry, Edward E. Louis, Aakrosh Ratan, Oscar C. Bedoya-Reina, Richard C. Burhans, Runhua Lei, Steig E. Johnson, Stephan C. Schuster, Webb Miller

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

We performed a population genomics study of the aye-aye, a highly specialized nocturnal lemur from Madagascar. Aye-ayes have low population densities and extensive range requirements that could make this flagship species particularly susceptible to extinction. Therefore, knowledge of genetic diversity and differentiation among aye-aye populations is critical for conservation planning. Such information may also advance our general understanding of Malagasy biogeography, as aye-ayes have the largest species distribution of any lemur. We generated and analyzed whole-genome sequence data for 12 aye-ayes from three regions of Madagascar (North, West, and East). We found that the North population is genetically distinct, with strong differentiation from other aye-ayes over relatively short geographic distances. For comparison, the average FST value between the North and East aye-aye populations - separated by only 248 km - is over 2.1-times greater than that observed between human Africans and Europeans. This finding is consistent with prior watershed- and climate-based hypotheses of a center of endemism in northern Madagascar. Taken together, these results suggest a strong and long-term biogeogra-phical barrier to gene flow. Thus, the specific attention that should be directed toward preserving large, contiguous aye-aye habitats in northern Madagascar may also benefit the conservation of other distinct taxonomic units. To help facilitate future ecological- and conservation- motivated population genomic analyses by noncom-putational biologists, the analytical toolkit used in this study is available on the Galaxy Web site.

Original languageEnglish (US)
Pages (from-to)5823-5828
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number15
DOIs
StatePublished - Apr 9 2013

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Aye-aye population genomic analyses highlight an important center of endemism in northern Madagascar'. Together they form a unique fingerprint.

  • Cite this