B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells

Phillip P. Domeier, Sathi Babu Chodisetti, Stephanie L. Schell, Yuka Imamura, Melinda J. Fasnacht, Chetna Soni, Ziaur Rahman

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The B-cell-intrinsic mechanisms of type 1 interferon (T1IFN) signaling in regulating B cell tolerance is unclear. Domeier et al. show that T1IFN signaling in B cells causes loss of B cell tolerance, promoting autoreactive B cell development into the antibody-forming cell and germinal center pathways by regulating BCR signaling.

Original languageEnglish (US)
Pages (from-to)406-418
Number of pages13
JournalCell Reports
Volume24
Issue number2
DOIs
StatePublished - Jul 10 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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