Bacillus Calmette-Guerin injections for melanoma immunotherapy: Potential for a false-positive PET/CT

Steven M. Sogge, Joseph Fotos, Mark Tulchinsky

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An 82-year-old woman presented for routine follow-up PET/CT after undergoing local melanoma resection in the left lower leg, isolated limb infusion chemotherapy, and immunomodulation therapy with Bacillus Calmette-Guérin (BCG) vaccine. Symmetric, bilateral, moderately intense FDG avid axillary and inguinal cutaneous nodules were observed that were new from the prior PETCT. The patient had developed skin lesions at the BCG injection sites several months before the study. The case raises awareness to PET/CT appearance of local inflammatory response to BCG injection, which could be mistaken by an unaware reader for recurrent melanoma.

Original languageEnglish (US)
Pages (from-to)368-369
Number of pages2
JournalClinical nuclear medicine
Volume40
Issue number4
DOIs
StatePublished - Apr 21 2015

Fingerprint

Mycobacterium bovis
Immunotherapy
Bacillus
Melanoma
Injections
BCG Vaccine
Skin
Immunomodulation
Groin
Leg
Extremities
Drug Therapy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "An 82-year-old woman presented for routine follow-up PET/CT after undergoing local melanoma resection in the left lower leg, isolated limb infusion chemotherapy, and immunomodulation therapy with Bacillus Calmette-Gu{\'e}rin (BCG) vaccine. Symmetric, bilateral, moderately intense FDG avid axillary and inguinal cutaneous nodules were observed that were new from the prior PETCT. The patient had developed skin lesions at the BCG injection sites several months before the study. The case raises awareness to PET/CT appearance of local inflammatory response to BCG injection, which could be mistaken by an unaware reader for recurrent melanoma.",
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Bacillus Calmette-Guerin injections for melanoma immunotherapy : Potential for a false-positive PET/CT. / Sogge, Steven M.; Fotos, Joseph; Tulchinsky, Mark.

In: Clinical nuclear medicine, Vol. 40, No. 4, 21.04.2015, p. 368-369.

Research output: Contribution to journalArticle

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